Intense burning phenomena (fire disasters) need to be prevented in the combustible gas utilization and transportation processes to ensure industrial safety. Nonmetallic spherical spacers (NSSs) have been investigated and applied in lots of explosive atmospheres to prevent explosion execution in a confined space. In this work, a novel fuzzy-based analytic hierarchy process (FAHP) is developed to take into account the uncertainty in decision-making and effectively solve the problem of factor weight allocation in multi-objective optimization. Optimal Latin Hypercube Design (Opt LHD), Chebyshev Orthogonal Polynomials (COP), and Adaptive Simulated Annealing (ASA) were combined. A multi-objective optimization method is proposed for the structural parameter optimization problem on NSSs in order to achieve conflicting multiple-objective optimization of low displacement rate and minimal deformation. That is to say, the small volume (low displacement rate) and high explosion-suppression performance (minimal deformation) of NSSs were optimized simultaneously. The results show that, compared with the original NSS model’s deformation (2.85 mm) and displacement rate (3.63%), the optimized NSSs with weight allocation had optimized the deformation by 12.98% and displacement rate by 6.1%. Compared with the optimized design model of NSSs without weight allocation with a deformation of 2.75 mm and a displacement rate of 3.48%, the deformation has been optimized by 9.82%, and the displacement rate has been optimized by 2.0%. It was verified that the proposed method is effective. At the same time, it was verified that the suppression effect of NSSs can be enhanced by changing the shape of the NSS spacer reasonably by experimental verification.