Load-bearing laminated glass (LG) elements take the form of simple members in buildings (i.e., columns, beams, and plates) or realize stand-alone assemblies, where glass and other traditional constructional materials can interact. Among several relevant aspects, the dynamic response of LG structures requires dedicated methods of analysis, towards the fulfilment of safe design purposes. A combination of multiple aspects must be taken into account for dynamic calculations of even simple LG elements when compared to static conditions, first of all the sensitivity of common interlayers to the imposed vibration frequency. The challenge is even more complex for the vibration serviceability assessment of in-service LG structures, where the degradation of materials and possible delamination effects could manifest, hence resulting in structural performances that can markedly differ from early-design conditions. Major uncertainties can be associated to the actual mechanical characterization of materials in use (especially the viscoelastic interlayers), as well as the contribution of restraints (as compared to ideal boundaries) and the possible degradation of the bonding layers (i.e., delaminations). All of these aspects are examined in the paper, with the support of extended analytical calculations, on-site experimental measurements, and parametric Finite Element (FE) numerical analyses. When compared to literature efforts accounting for ideal boundaries only, an analytical formulation is proposed to include the effects of flexible restraints in the dynamic performance of general (double) LG beams. Special care is also spent for the presence of possible delaminations, including size and position effects. In the latter case, existing formulations for composite laminates are preliminarily adapted to LG beams. Their reliability and accuracy is assessed with the support of test predictions and parametric FE simulations.