2023
DOI: 10.26434/chemrxiv-2023-mkdkx
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Dynamic Antimicrobial Poly(disulfide) Coatings Exfoliate Biofilms On-Demand via Triggered Depolymerization

Abstract: Bacterial biofilms are notoriously problematic in applications ranging from biomedical implants to fouling of ship hulls. Cationic, amphiphilic antibacterial surface coatings can delay the onset of biofilm formation by killing microbes on-contact, but they lose effectiveness over time due to non-specific binding of biomass and subsequent biofilm formation atop the fouled surface. Harsh physical or mechanical treatment methods are then required to forcibly expel the accumulated biomass and regenerate a clean su… Show more

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