Dynamic aspects of the stereochemistry of phenothiazines in solution. Part 2. Segmental motion and conformational analysis of the side-chain in promazines

The 'H NMR spectrum of chlorpromazine hydrochloride was fully assigned at 400 MHz Similarly, the "C NMR spectrum was assigned unambiguously using two-dimensional NMR. Measurements of chemical shift as a function of concentration in D,O showed appreciable changes of shift of both protons and carbons which were apparent even at solution concentrations two orders of magnitude lower than the critical micelle concentration (CMC). The relative magnitude of the shifts of the aromatic protons and carbons on dilution below the CMC were compatible with vertical stacking of the molecules in an off-set manner such that maximum overlap of the chlorinated rings occurred. Proton chemical shift data were interpreted using a stepwise association model to quantify the extent of association in the pre-CMC region.

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Conformation and Electronic Aspects of Chlor promazine in Solution

Dea

Keyzer

1986

Modern Bioelectrochemistry

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Dynamic aspects of the stereochemistry of phenothiazines in solution. Part 2. Segmental motion and conformational analysis of the side-chain in promazines

Cited by 8 publications

References 1 publication

ChemInform Abstract: DYNAMIC ASPECTS OF THE STEREOCHEMISTRY OF PHENOTHIAZINES IN SOLUTION. PART 2. EGMENTAL MOTION AND CONFORMATIONAL ANALYSIS OF THE SIDE‐CHAIN IN PROMAZINES

ChemInform Abstract: DYNAMIC ASPECTS OF THE STEREOCHEMISTRY OF PHENOTHIAZINES IN SOLUTION. PART 2. EGMENTAL MOTION AND CONFORMATIONAL ANALYSIS OF THE SIDE‐CHAIN IN PROMAZINES

¹H and ¹³C NMR studies of the self‐association of chlorpromazine hydrochloride in aqueous solution

Conformation and Electronic Aspects of Chlor promazine in Solution

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Dynamic aspects of the stereochemistry of phenothiazines in solution. Part 2. Segmental motion and conformational analysis of the side-chain in promazines

Cited by 8 publications

References 1 publication

ChemInform Abstract: DYNAMIC ASPECTS OF THE STEREOCHEMISTRY OF PHENOTHIAZINES IN SOLUTION. PART 2. EGMENTAL MOTION AND CONFORMATIONAL ANALYSIS OF THE SIDE‐CHAIN IN PROMAZINES

ChemInform Abstract: DYNAMIC ASPECTS OF THE STEREOCHEMISTRY OF PHENOTHIAZINES IN SOLUTION. PART 2. EGMENTAL MOTION AND CONFORMATIONAL ANALYSIS OF THE SIDE‐CHAIN IN PROMAZINES

1H and 13C NMR studies of the self‐association of chlorpromazine hydrochloride in aqueous solution

Conformation and Electronic Aspects of Chlor promazine in Solution

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¹H and ¹³C NMR studies of the self‐association of chlorpromazine hydrochloride in aqueous solution