Dynamic assessment of myocardial involvement in patients with end‐stage renal disease by ultrasonic tissue characterization and serum markers of collagen metabolism

Fatema, Kaniz; Hirono, Osamu; Masakane, Ikuto; Nitobe, Joji; Kaneko, Kazuyoshi; Zhang, Xuehua; Takeishi, Yasuchika

doi:10.1002/clc.4960270412

Cited by 9 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While collagen types I and III are identified in human atherosclerotic plaques, type III collagen has been suggested to be the major platelet activator after plaque rupture evoking ACS [ 36 ], further reinforcing the importance of our conclusions in NOD1 on the pathophysiology of atherothrombosis. Nevertheless, uncontrolled collagen accumulation can cause arterial stenosis and changes in fiber composition contribute to the development of arterial stiffness [ 37 , 38 ]. Therefore, future assessment of the dynamic balance between degradation and synthesis of collagen might be required to investigate differential affections by Nod1 ablation.…”

Section: Discussionmentioning

confidence: 99%

Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis

González-Ramos

Fernández-García

Recalde

et al. 2020

Cells

View full text Add to dashboard Cite

Atherothrombosis, the main cause of acute coronary syndromes (ACS), is characterized by the rupture of the atherosclerotic plaque followed by the formation of thrombi. Fatal plaque rupture sites show large necrotic cores combined with high levels of inflammation and thin layers of collagen. Plaque necrosis due to the death of macrophages and smooth muscle cells (SMCs) remains critical in the process. To determine the contribution of the innate immunity receptor NOD1 to the stability of atherosclerotic plaque, Apoe−/− and Apoe−/− Nod1−/− atherosclerosis prone mice were placed on a high-fat diet for 16 weeks to assess post-mortem advanced atherosclerosis in the aortic sinus. The proliferation and apoptosis activity were analyzed, as well as the foam cell formation capacity in these lesions and in primary cultures of macrophages and vascular SMCs obtained from both groups of mice. Our results reinforce the preeminent role for NOD1 in human atherosclerosis. Advanced plaque analysis in the Apoe−/− atherosclerosis model suggests that NOD1 deficiency may decrease the risk of atherothrombosis by decreasing leukocyte infiltration and reducing macrophage apoptosis. Furthermore, Nod1−/− SMCs exhibit higher proliferation rates and decreased apoptotic activity, contributing to thicker fibrous caps with reduced content of pro-thrombotic collagen. These findings demonstrate a direct link between NOD1 and plaque vulnerability through effects on both macrophages and SMCs, suggesting promising insights for early detection of biomarkers for treating patients before ACS occurs.

show abstract

Section: Discussionmentioning

confidence: 99%

Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis

González-Ramos

Fernández-García

Recalde

et al. 2020

Cells

View full text Add to dashboard Cite

show abstract

“…Several post-mortem studies have shown MF in patients with CKD [9][10][11], and it has been proposed that the development of LV diastolic dysfunction (LVDD) and subsequent HFpEF in CKD patients is related to MF [12]. Although some studies have explored MF in patients with end-stage CKD using circulating collagen-related biomarkers [13,14], no information is available on serum PICP and CITP/MMP-1 ratio in CKD patients with HF. Therefore, this study was designed to assess in hypertensive patients with HFpEF the potential influence of CKD on the biomarker combination corresponding to the histomolecular phenotype of mMF and the association of this combination with LVDD in these patients.…”

Section: Introductionmentioning

confidence: 99%

Does Chronic Kidney Disease Facilitate Malignant Myocardial Fibrosis in Heart Failure with Preserved Ejection Fraction of Hypertensive Origin?

Eirós

Romero‐González

Gavira

et al. 2020

JCM

View full text Add to dashboard Cite

In hypertensive patients with heart failure (HF) a serum biomarker combination of high carboxy-terminal propeptide of procollagen type-I (PICP) and low carboxy-terminal telopeptide of collagen type-I to matrix metalloproteinase-1 (CITP:MMP-1) ratio identifies a histomolecular phenotype of malignant myocardial fibrosis (mMF) associated with severe diastolic dysfunction (DD) and poor outcomes. As chronic kidney disease (CKD) facilitates MF and DD, we investigated the influence of CKD on the mMF biomarker combination in HF patients with preserved ejection fraction (HFpEF). Hypertensives (n = 365), 232 non-HF and 133 HFpEF, were studied, and 35% non-HF and 46% HFpEF patients had CKD (estimated glomerular filtration rate < 60 mL/min/1.73 m2 or urine albumin-to-creatinine ratio ≥ 30 mg/g). Specific immunoassays were performed to determine biomarkers. Medians were used to establish the high PICP and low CITP:MMP-1 combination. A comparison with non-HF showed that the biomarker combination presence was increased in HFpEF patients, being associated with CKD in all patients. CKD influenced the association of the biomarker combination and HFpEF (p for interaction ≤ 0.019). The E:e’ ratio was associated with the biomarker combination in CKD patients. Among CKD patients with HFpEF, those with the biomarker combination exhibited higher (p = 0.016) E:e’ ratio than those without the pattern. These findings suggest that CKD facilitates the development of biomarker-assessed mMF and DD in hypertensive HFpEF patients.

show abstract

“…Regression of ultrasonic myocardial texture alterations have been already documented in clinical scenarios of hypertrophy regression [ 26 , 27 ]. Although our results showed a trend toward regression of both IBS indices (CC IBS and CV) after treatment of patients with overt hypothyroidism or hyperthyroidism, this was only statistical significant in CV of hypothyroidism patients.…”

Section: Discussionmentioning

confidence: 99%

Myocardial ultrasonic tissue characterization in patients with thyroid dysfunction

Romano

Maciel

Almeida-Filho

et al. 2010

Cardiovasc Ultrasound

View full text Add to dashboard Cite

BackgroundStructural myocardial abnormalities have been extensively documented in hypothyroidism. Experimental studies in animal models have also shown involvement of thyroid hormones in gene expression of myocardial collagen. This study was planned to investigate the ability of ultrasonic tissue characterization, as evaluated by integrated backscatter (IBS), to early identify myocardial involvement in thyroid dysfunction.Patients and MethodsWe studied 15 patients with hyperthyroidism (HYPER), 8 patients with hypothyroidism (HYPO), 14 patients with subclinical hypothyroidism (SCH) and 19 normal (N) subjects, who had normal LV systolic function. After treatment, 10 HYPER, 6 HYPO, and 8 SCH patients were reevaluated. IBS images were obtained and analyzed in parasternal short axis (papillary muscle level) view, at left ventricular (LV) posterior wall. The following IBS variables were analyzed: 1) the corrected coefficient (CC) of IBS, obtained by dividing IBS intensity by IBS intensity measured in a rubber phantom, using the same equipment adjustments, at the same depth; 2) cardiac cyclic variation (CV) of IBS - peak-to-peak difference between maximal and minimal values of IBS during cardiac cycle; 3) cardiac cyclic variation index (CVI) of IBS - percentual relationship between the cyclic variation (CV) and the mean value of IBS intensity.ResultsCC of IBS was significantly larger (p < 0.05) in HYPER (1.57 ± 0.6) and HYPO (1.53 ± 0.3) as compared to SCH (1.32 ± 0.3) or N (1.15 ± 0.27). The CV (dB) (HYPO: 7.5 ± 2.4; SCH: 8.2 ± 3.1; HYPER: 8.2 ± 2.0) and the CVI (HYPO: 35.6 ± 19.7%; SCH: 34.7 ± 17.5%; HYPER: 37.8 ± 11.6%) were not significantly different in patients with thyroid dysfunction as compared to N (7.0 ± 2.0 and 44.5 ± 15.1%).ConclusionsCC of IBS was able to differentiate cardiac involvement in patients with overt HYPO and HYPER who had normal LV systolic function. These early myocardial structural abnormalities were partially reversed by drug therapy in HYPER group. On the other hand, although mean IBS intensity tended to be slightly larger in patients with SCH as compared to N, this difference was not statistical significant.

show abstract

Dynamic assessment of myocardial involvement in patients with end‐stage renal disease by ultrasonic tissue characterization and serum markers of collagen metabolism

Cited by 9 publications

References 36 publications

Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis

Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis

Does Chronic Kidney Disease Facilitate Malignant Myocardial Fibrosis in Heart Failure with Preserved Ejection Fraction of Hypertensive Origin?

Myocardial ultrasonic tissue characterization in patients with thyroid dysfunction

Contact Info

Product

Resources

About