2024
DOI: 10.1002/ange.202410351
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Dynamic Asymmetric Diamination of Allylic Alcohols through Borrowing Hydrogen Catalysis: Diastereo‐Divergent Synthesis of Tetrahydrobenzodiazepines

Yufeng Liu,
Peng Ji,
Gongfeng Zou
et al.

Abstract: We present herein an unprecedented, catalytic enantioconvergent diamination of racemic allylic alcohols with the construction of two C‐N bonds and 1,3‐nonadjacent stereocenters. This iridium/chiral phosphoric acid cooperative catalytic system operates through an atom‐economical borrowing hydrogen amination/aza‐Michael cascade, and converts readily available phenylenediamines and racemic allylic alcohols to 1,5‐tetrahydrobenzodiazepines in high enantioselectivity. An intriguing solvent‐dependent switch of diast… Show more

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