Dynamic Axial Chirality in Drug Design and Discovery: Introduction to Atropisomerism, Classification, Significance, Recent Trends and Challenges

Joshi, Gaurav; Kaur, Manpreet; Kumar, Raj

doi:10.1007/978-981-15-5534-3_4

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Classification Of Atropisomers1

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2021

2022

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“…In addition to classical atropisomers, compounds containing hindered single bonds, such as CCO, CN, and CB, can also yield atropisomers due to sufficient steric hindrance 28 . In addition, atropisomers with CS, CP, and NN axes have recently been reported 29,30 .…”

Section: Classification Of Atropisomersmentioning

confidence: 99%

A nonneglectable stereochemical factor in drug development: Atropisomerism

Yang

2022

Chirality

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Chirality is one of the key factors affecting the medicinal efficacy of compounds. In addition to central chirality, sterically hindered chiral axes commonly appear in drugs and the resulting chirality is known as atropisomerism. With developments in medicinal chemistry, atropisomerism has attracted increasing attention. This review discusses the classification, biological activity, pharmacokinetics, toxicity and side effects of atropisomers, and can serve as a reference in the research and development of potential chiral drugs.

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Section: Classification Of Atropisomersmentioning

confidence: 99%