This chapter will inform higher education faculty and students on a broad spectrum as to the different levels of using groups within PBL. This chapter begins with an overview of PBL and the integration of using groups within the online setting. The chapter also discusses the notion of good teaching requirements using a variety of means and appropriate responses in various situations. Problem-based learning is a long-established form of student-centered learning. The foundation of PBL in academic settings is to increase student engagement and encourage interactive learning. Next, PBL in peer teams will be discussed with integrating interactive learning, and details of what this means in higher education and how to use various media to enhance student collaboration will be given. This chapter will include discussions to using peer teams in problem-based learning classrooms. Finally, the use of peer tutors in PBL classrooms in higher education will be included in addition to the various types of peer tutoring that are foundational to 21st century learning.