Dynamic behavior of surfactant films

A Theoretical Model of Pulmonary Surfactant Multilayer Collapse under Oscillating Area Conditions

“…Under low concentration conditions, the present model contains kinetics (adsorption/desorption and diffusion) similar as to those of previous models for determining surfactant hysteresis in an oscillating bubble system (17,21,22). However, while Horn and Davis (23) pinpointed viscoelasticity of the interface as the most probable cause of P-V hysteresis, that study did not consider the effects of collapse and respreading, which can be extremely important (2,16).…”

“…In these devices, as in the lung, a surfactant monolayer can collapse when compressed to high surface concentrations (4,7). Monolayer collapse and respreading have been hypothesized as essential in the development of the characteristic surface tension-area (S-A) loops associated with pulmonary surfactant at high concentrations (2,16). For example, Fig.…”

“…Additionally, our model includes monolayer collapse (multilayer formation) and respreading mechanisms. Other researchers (2,16) have speculated that multilayer dynamics are central in forming the large hysteresis areas at high bulk concentrations. These dynamics have not been included in model studies heretofore.…”

Roles of γ-Globulin in the Dynamic Interfacial Behavior of Mixed Dipalmitoyl Phosphatidylcholine/γ-Globulin Monolayers at Air/Liquid Interfaces

“…There are two possible mechanisms that may result in hysteresis behavior. One is that significant desorption occurred during the compression stage, thus resulting in less molecules at the interface (31). The other is that the respreading of molecules at the interface was slow compared to the expansion of interfacial area (32).…”

Equilibrium and metastable states in lecithin films

“…Monolayers containing lecithin have been used as models for studying phase relations in lipid bilayers and cell membranes (4,5,7,11,16,17,21), and for lung surfactant in the study of the mechanics of the lung (1,6,8,12,13,20,23). The significance of many of the studies with synthetic lecithins is, for us, uncertain because of the variability of the surface pressure (ir) surface area (A) isotherms observed by different investigators (3,7,8,17,(21)(22)(23).…”