The paper considers elastic anisotropic nanoâsheet with nanotopography and containing embedded nanocavities under timeâharmonic inâplane wave motion. The mechanical model is based on the classical elastodynamic theory for the anisotropic bulk solid and the nonclassical boundary conditions along its boundary derived by Gurtin and Murdoch. A localized constitutive equation for the halfâplane boundary is considered in the frame of surface elasticity theory. The computational tool is an efficient direct displacement boundary element method (BEM) based on the frequencyâdependent elastodynamic fundamental solution for elastic generally anisotropic material. To show the versatility of the proposed methodology, wave propagation in an elastic anisotropic heterogeneous nanoâsheet with nanorelief presented by hillâcanyon nanotopography is studied. The simulations illustrate the dependence of the wave field on the material anisotropy, on the surface elasticity properties, on the nanorelief peculiarities, on the nanocavities existence and their dynamic interaction, and on the incident wave characteristics. The obtained results reveal the potential of the developed mechanical model based on the boundary integral equations in the frame of surface elasticity theory to produce highly accurate results by using strongly reduced discretization mesh in comparison with the domainâbased methods.