Dynamic Bone Quality: A Noninvasive Measure of Bone's Biomechanical Property in Osteoporosis

Bhattacharya, Amit; Watts, Nelson B.; Davis, Kermit G.; Kotowski, Susan; Shukla, Rakesh; Dwivedi, Alok; Coleman, Robert E.

doi:10.1016/j.jocd.2010.01.001

Cited by 18 publications

(15 citation statements)

References 37 publications

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“…The current experiments differ from this work, since we used a frequency range of 0.5 to 20 Hz. This lower frequency range is consistent with previously performed mouse loading studies, in addition to results from clinical data that demonstrated importance of the phase shift angle in this range [2]. …”

Section: Discussionsupporting

confidence: 91%

“…Damping is the potential of the whole musculoskeletal system to effectively dissipate energy associated with loading. A recent set of clinical data indicates that postmenopausal women with vertebral fractures have low damping capacity at a number of different skeletal sites [2]. This intriguing observation suggests a potential, non-invasive diagnostic tool for evaluating susceptibility of bone fracture.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical loading, damping, and load-driven bone formation in mouse tibiae

Dodge

Wanis

Ayoub

et al. 2012

Bone

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Mechanical loads play a pivotal role in the growth and maintenance of bone and joints. Although loading can activate anabolic genes and induce bone remodeling, damping is essential for preventing traumatic bone injury and fracture. In this study we investigated the damping capacity of bone, joint tissue, muscle, and skin using a mouse hindlimb model of enhanced loading in conjunction with finite element modeling to model bone curvature. Our hypothesis was that loads were primarily absorbed by the joints and muscle tissue, but that bone also contributed to damping through its compression and natural bending. To test this hypothesis, fresh mouse distal lower limb segments were cyclically loaded in axial compression in sequential bouts, with each subsequent bout having less surrounding tissue. A finite element model was generated to model effects of bone curvature in silico. Two damping-related parameters (phase shift angle and energy loss) were determined from the output of the loading experiments. Interestingly, the experimental results revealed that the knee joint contributed to the largest portion of the damping capacity of the limb, and bone itself accounted for approximately 38% of the total phase shift angle. Computational results showed that normal bone curvature enhanced the damping capacity of the bone by approximately 40%, and the damping effect grew at an accelerated pace as curvature was increased. Although structural curvature reduces critical loads for buckling in beam theory, evolution apparently favors maintaining curvature in the tibia. Histomorphometric analysis of the tibia revealed that in response to axial loading, bone formation was significantly enhanced in the regions that were predicted to receive a curvature-induced bending moment. These results suggest that in addition to bone’s compressive damping capacity, surrounding tissues, as well as naturally-occurring bone curvature, also contribute to mechanical damping, which may ultimately affect bone remodeling and bone quality.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Mechanical loading, damping, and load-driven bone formation in mouse tibiae

Dodge

Wanis

Ayoub

et al. 2012

Bone

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“…Although some studies have shown significant correlation between grip strength, biomechanical property and BMD [19,20], there was no significant correlation among these markers in the current study.…”

Section: Discussioncontrasting

confidence: 85%

Establishment of a murine model for radiation-induced bone loss using micro-computed tomography in adult C3H/HeN mice

Lee

Yang

et al. 2013

Lab Anim Res

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Bone changes are common sequela of radiation therapy for cancer. The purpose of this study was to establish an experimental model of radiation-induced bone loss in adult mice using micro-computed tomography (µCT). The extent of changes following 2 Gy gamma irradiation (2 Gy/min) was studied at 4, 8, 12 or 16 weeks after exposure. Adult mice that received 1, 2, 4 or 6 Gy of gamma-rays were examined 12 weeks after irradiation. Tibiae were analyzed using µCT. Serum markers and biomechanical properties were measured and the osteoclast surface was examined. A significant loss of trabecular bone in tibiae was evident 12 weeks after exposure. Measurements performed after irradiation showed a dose-related decrease in trabecular bone volume fraction (BV/TV) and bone mineral density (BMD), respectively. The best-fitting dose-response curves were linear-quadratic. Taking the controls into accounts, the lines of best fit were as follows: BV/TV (%)= -0.071D2-1.799D+18.835 (r2=0.968, D=dose in Gy) and BMD (mg/cm3) = -3.547D2-14.8D+359.07 (r2=0.986, D=dose in Gy). Grip strength and body weight did not differ among the groups. No dose-dependent differences were apparent among the groups with regard to mechanical and anatomical properties of tibia, serum biochemical markers and osteoclast activity. The findings provide the basis required for better understanding of the results that will be obtained in any further studies of radiation-induced bone responses.

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“…Well‐designed large studies are needed to find precise beneficial doses in vivo and in clinical trials. Although some studies have shown significant correlation between grip strength, biomechanical property and BMD (Bhattacharya et al ., ; Di Monaco et al ., ), there was no significant correlation among these markers in this study. The application of Cimicifuga species for osteoporotic bone changes is continually discussed.…”

Section: Resultsmentioning

confidence: 98%

Evaluation of the Antiosteoporotic Potential of Cimicifuga heracleifolia in Female Mice

Ahn

Yang

Jang

et al. 2011

Phytotherapy Research

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Cimicifugae rhizoma might be protective against osteoporosis. This study investigated the effects of Cimicifuga heracleifolia (CH), an Asian species of Cimicifugae rhizome, on bone loss in ovariectomized (OVX) mice. The C3H/HeN mice were divided into sham and OVX groups. The OVX mice were treated with vehicle, 17β-estradiol (E(2) ) or CH for 6 weeks. Serum calcium, phosphorus, E(2) concentration and serum alkaline phosphatase (ALP) activity were measured. Tibiae and femora were analysed using microcomputed tomography. The biomechanical property and osteoclast surface level were measured. Treatment with CH (i.p., 50 mg/kg of body weight, every other day) prevented the OVX-induced increase in body weight but did not alter the uterus weight of the OVX mice. Serum ALP levels and osteoclast surface levels in the OVX mice were reduced by treatment with CH. The CH significantly preserved trabecular bone mass, bone volume, trabecular number, trabecular thickness, structure model index and bone mineral density of proximal tibia metaphysis or distal femur metaphysis. However, grip strength, mechanical property and cortical bone architecture did not differ among the experimental groups. The results indicate that the supply of CH can prevent OVX-induced bone loss in mice.

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Dynamic Bone Quality: A Noninvasive Measure of Bone's Biomechanical Property in Osteoporosis

Cited by 18 publications

References 37 publications

Mechanical loading, damping, and load-driven bone formation in mouse tibiae

Mechanical loading, damping, and load-driven bone formation in mouse tibiae

Establishment of a murine model for radiation-induced bone loss using micro-computed tomography in adult C3H/HeN mice

Evaluation of the Antiosteoporotic Potential of Cimicifuga heracleifolia in Female Mice

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