Dynamic breast MRI with spiral trajectories: 3D versus 2D

Yen, Yi‐Fen; Han, Karen F.; Daniel, Bruce L.; Heiss, Steve; Birdwell, Robyn L.; Herfkens, Robert J.; Sawyer-Glover, Anne M.; Glover, Gary H.

doi:10.1002/(sici)1522-2586(200004)11:4<351::aid-jmri2>3.0.co;2-l

Cited by 36 publications

(27 citation statements)

References 22 publications

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“…Contrast-enhanced images were obtained using an interleaved rapid dynamic and highspatial-resolution protocol designed to capture the rate of enhancement as well as the morphologic features of any enhancing lesion during and after a single-bolus, antecubital, intravenous injection of 0.1 mmol/kg gadolinium contrast agent. 32 Initial dynamic imaging consisted of whole-breast, 3-dimensional spiral images 33 34 (TR, 33; TE, 9 msec; flip angle, 50 degrees; FOV, 20 cm; matrix, 512 ϫ 192 pixels; number of slices, 63; slice thickness, 1.5-2.0 mm; with water-selective, spectral-spatial excitation on resonance 1-2-1 MT suppression pulse). An additional 260 seconds of dynamic imaging were performed immediately after the high-resolution scan to capture the rate of wash-out of contrast from the breast.…”

Section: Mr Protocolmentioning

confidence: 99%

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Hartman

Daniel

Kurian

et al. 2004

Cancer

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Surface tension and viscosity are the important properties of liquid binders affecting wet granulation processes. They could be used to control solids flow pattern and relative motion of particles for controlling wetting, granule growth, consolidation, and breakage. This study aims to investigate experimentally the impacts of the two properties with a conical high shear granulator. The results show significant effects of viscosity and surface tension on solids flow pattern and relative motion of particles. The relative importance of the two parameters, the surface tension and the viscosity, are found to vary with the axial and radial positions in the granulator. For example, the viscosity force decreases with an increase in the bed height in the axial direction (vertical plane). The viscosity force between particles coated with PEG4000 solution is in mN order, whereas that between particles coated with ethanol and water is in μN order. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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Section: Mr Protocolmentioning

confidence: 99%

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Hartman

Daniel

Kurian

et al. 2004

Cancer

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“…Although the results of investigation to date have varied greatly, the sensitivity of breast DCE, T1-weighted MRI for malignancy has consistently been reported to be excellent (88-100%) (7)(8)(9)(10)(11)(12)(13)(14)(15). Qualitative analyses of the temporal changes in signal intensity following bolus CR injection have shown that malignant tissues generally enhance early, with rapid, large increase in signal intensity as compared with benign tissues.…”

Section: Backround and Rationalementioning

confidence: 99%

“…This is presumably due to the inherent leakiness of the tumor vasculature and/or increased vascularization. However, the specificity of DCE MRI has been rather variable, ranging from 37-97% (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Recently, T2 * -weighted perfusion MRI (17)(18)(19), as well as the technique of 1 H MR spectroscopy (MRS) (20)(21)(22) have also been examined as promising tool for improving the specificity of breast malignancy detection.…”

Section: Backround and Rationalementioning

confidence: 99%

Clinically Practical Magnetic Resonance Protocol for Improved Specificity in Breast Cancer Diagnosis

Tudorica¹

2008

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“…Numerous methods exist for the implementation of each of the above steps: T1 and M 0 maps can be acquired with several techniques; [3][4][5][6] different mathematical models can be used to analyze the dynamic data; [7][8][9][10][11][12][13][14] and finally, various pulse sequences differing in sampling strategies and acquisition parameters have been developed to sample the signal in k-space. [15][16][17][18] The vast majority of preclinical sampling strategies used for DCE-MRI acquire a limited number of relatively thick slices. Volume averaging and limited coverage make it difficult to characterize the heterogeneity in the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models

et al. 2013

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Purpose: Dynamic contrast-enhanced (DCE) MRI has been widely used as a quantitative imaging method for monitoring tumor response to therapy. The simultaneous challenges of increasing temporal and spatial resolution in a setting where the signal from the much smaller voxel is weaker have made this MR technique difficult to implement in small-animal imaging. Existing protocols employed in preclinical DCE-MRI acquire a limited number of slices resulting in potentially lost information in the third dimension. This study describes and compares a family of four-dimensional (3D spatial + time), projection acquisition, radial keyhole-sampling strategies that support high spatial and temporal resolution. Methods: The 4D method is based on a RF-spoiled, steady-state, gradient-recalled sequence with minimal echo time. An interleaved 3D radial trajectory with a quasi-uniform distribution of points in k-space was used for sampling temporally resolved datasets. These volumes were reconstructed with three different k-space filters encompassing a range of possible radial keyhole strategies. The effect of k-space filtering on spatial and temporal resolution was studied in a 5 mM CuSO 4 phantom consisting of a meshgrid with 350-μm spacing and in 12 tumors from three cell lines (HT-29, LoVo, MX-1) and a primary mouse sarcoma model (three tumors/group). The time-to-peak signal intensity was used to assess the effect of the reconstruction filters on temporal resolution. As a measure of heterogeneity in the third dimension, the authors analyzed the spatial distribution of the rate of transport (K trans ) of the contrast agent across the endothelium barrier for several different types of tumors. Results: Four-dimensional radial keyhole imaging does not degrade the system spatial resolution. Phantom studies indicate there is a maximum 40% decrease in signal-to-noise ratio as compared to a fully sampled dataset. T1 measurements obtained with the interleaved radial technique do not differ significantly from those made with a conventional Cartesian spin-echo sequence. A bin-by-bin comparison of the distribution of the time-to-peak parameter shows that 4D radial keyhole reconstruction does not cause significant temporal blurring when a temporal resolution of 9.9 s is used for the subsamples of the keyhole data. In vivo studies reveal substantial tumor heterogeneity in the third spatial dimension that may be missed with lower resolution imaging protocols. Conclusions: Volumetric keyhole imaging with projection acquisition provides a means to increase spatiotemporal resolution and coverage over that provided by existing 2D Cartesian protocols. Furthermore, there is no difference in temporal resolution between the higher spatial resolution keyhole reconstruction and the undersampled projection data. The technique allows one to measure complex heterogeneity of kinetic parameters with isotropic, microscopic spatial resolution.

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Dynamic breast MRI with spiral trajectories: 3D versus 2D

Cited by 36 publications

References 22 publications

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Clinically Practical Magnetic Resonance Protocol for Improved Specificity in Breast Cancer Diagnosis

A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models

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