The objective of this innovative research is assessment of dynamic stability for a hybrid nanocomposite polymer beam. The considered beam formed by multiphase nanocomposite, including polymer–carbon nanotubes (CNTs)–carbon fibers (CFs). Hence, as to compute the effective material characteristics related to multiphase nanocomposite layers, the Halpin–Tsai model, as well as micromechanics equations are employed. To model the structure realistically, exponential shear deformation beam theory (ESDBT) is applied and using energy methods, governing equations are achieved. Moreover, differential quadrature method (DQM) as well as Bolotin procedures are used for solving the obtained governing equations and the dynamic instability region (DIR) relative to the beam is determined. To extend this novel research, various parameters pinpointing the influences of CNT volume fraction, CFs volume percent, boundary edges as well as the structure’s geometric variables on the dynamic behavior of the beam are presented. The results were validated with the theoretical and experimental results of other published papers. The outcomes reveal that increment of volume fraction of CNT is able to shift DIR to more amounts of frequency. Further, rise of carbon fibers volume percent leads to increase the excitation frequency of this structure.