Dynamic causal modeling of load-dependent modulation of effective connectivity within the verbal working memory network

Dima, Danai; Jogia, Jigar; Frangou, Sophia

doi:10.1002/hbm.22382

Cited by 57 publications

(83 citation statements)

References 41 publications

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“…Successful maintenance of information in working memory is associated with increased cortical phase synchronization [9,14,15]. From a neurophysiological point of view, in both verbal and visuospatial working memory tasks, the bilateral prefrontal (PFC) and posterior parietal (PPC) cortices are activated [16][17][18]. Theta phase synchronization during a working memory task is sustained during encoding, maintenance, and retrieval between these two anatomical regions and increases with memory load (difficulty of the task) [9,19].…”

Section: Introductionmentioning

confidence: 99%

The effect of binaural beats on verbal working memory and cortical connectivity

et al. 2017

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Objective. Synchronization in activated regions of cortical networks affect the brain’s frequency response, which has been associated with a wide range of states and abilities, including memory. A non-invasive method for manipulating cortical synchronization is binaural beats. Binaural beats take advantage of the brain’s response to two pure tones, delivered independently to each ear, when those tones have a small frequency mismatch. The mismatch between the tones is interpreted as a beat frequency, which may act to synchronize cortical oscillations. Neural synchrony is particularly important for working memory processes, the system controlling online organization and retention of information for successful goal-directed behavior. Therefore, manipulation of synchrony via binaural beats provides a unique window into working memory and associated connectivity of cortical networks. Approach. In this study, we examined the effects of different acoustic stimulation conditions during an N-back working memory task, and we measured participant response accuracy and cortical network topology via EEG recordings. Six acoustic stimulation conditions were used: None, Pure Tone, Classical Music, 5 Hz binaural beats, 10 Hz binaural beats, and 15 Hz binaural beats. Main results. We determined that listening to 15 Hz binaural beats during an N-Back working memory task increased the individual participant’s accuracy, modulated the cortical frequency response, and changed the cortical network connection strengths during the task. Only the 15 Hz binaural beats produced significant change in relative accuracy compared to the None condition. Significance. Listening to 15 Hz binaural beats during the N-back task activated salient frequency bands and produced networks characterized by higher information transfer as compared to other auditory stimulation conditions.

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Section: Introductionmentioning

confidence: 99%

The effect of binaural beats on verbal working memory and cortical connectivity

et al. 2017

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“…The intervention aims to enhance cognitive control of emotional information processing by specifically targeting abnormal activation patterns in dlPFC and amygdala that underlie the cognitive control and emotion regulation impairments observed in MDD. To accomplish this, the intervention combined working memory and facial affect identification tasks, which have been shown to specifically target activity in the dlPFC [72] and amygdala [73], respectively. The task performed during the intervention requires that patients identify the emotions expressed on a series of faces displayed on a computer screen while remembering the specific sequence of faces.…”

Section: Neuroplasticitymentioning

confidence: 99%

Neuroscience-Informed Cognitive-Affective Training Interventions for Mood and Anxiety Disorders

Alvarez

Iacoviello

2015

Curr Treat Options Psych

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Mood and anxiety disorders are characterized by abnormally persistent affective states. Neuroimaging studies have implicated the functioning of specific brain regions in the aberrant affective processing observed in mood and anxiety disorders: enhanced engagement of subcortical regions responsible for affect generation (amygdala, hippocampus) is coupled with reduced inhibitory cognitive control of affective processing from dorsolateral and ventrolateral prefrontal cortices. Emerging but compelling evidence suggests that neuroplastic mechanisms can be harnessed to remediate these abnormalities, thus offering the prospect of new therapeutic interventions. Cognitive-affective training is a particularly promising strategy for enhancing cognitive control over affective processes via modulation of these abnormally functioning neural networks. This paper presents a review of the current literature and a justification for developing cognitive-affective training, and proposes initial evidence for the efficacy of cognitive-affective training interventions. Cognitive-affective training interventions could represent a novel method for targeting perseverative thinking and negative affective biases in mood and anxiety disorders.

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“…There have been a number of recent studies investigating WM in a DCM framework. report task--related increase in directed connectivity from posterior parietal cortex to inferior frontal cortex and middle frontal gyrus and similarly, Dima et al (2014) found WM--load increases in connectivity from right PC to right dlPFC.…”

Section: Introductionmentioning

confidence: 71%

“…The modulation of the forward connection contrasts with the modulation of the backward connection seen by . Dima et al (2014) similarly see increased connectivity from PC to dlPFC, using a verbal N--Back WM task, and using DCM to model the activity of bilateral PC, dlPFC and ACC.…”

Section: Brain Functional Connectivity and Working Memorymentioning

confidence: 81%

“…While Dima et al (2014) constrained their model space to only allow (WM--load) driving input into the parietal cortex, tested the most likely region of WM input with connectivity modulations absent, and found this to be the parietal cortex. The study of differed from the present study in that the task paradigm was a delayed matching to sample task, and the networks used in DCM were considerably more complex, involving 8 bilateral regions of interest.…”

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confidence: 99%

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Genetics of functional brain networks

Sinclair¹

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In this thesis, the heritability of a number of features of brain functional connectivity and network behaviour was estimated, in order to assess their suitability as imaging endophenotypes. Phenotypes were chosen based on prior association with psychiatric disease in the literature, and current interest in the neuroimaging community. Heritability was estimated using a large MRI twin sample from the Queensland Twin Imaging Study.The first study looks at intrinsic functional brain networks present at rest, in the absence of cognitive demand, and characterised them using graph theory, a mathematical formulation used to describe topological properties of complex networks. Such characteristics were found to be moderately to strongly heritable (h 2 =20--60%). The heritability estimates varied substantially with methodological choices, in particular the removal or inclusion of global signal.Connectivity of functional brain networks during working memory performance were also examined. Dynamic causal modelling was employed to determine task--related changes in functional coupling between frontal and parietal regions. Changes in connectivity with task demand were observed for both forward and backwards connections, but the changes had low test--retest reliability (ICC≤0.3), and subsequently, twin correlations and heritability were non--significant (rMZ≤0.08, rDZ≤--0.05).Finally the functional connectivity profile of the dorsolateral prefrontal cortex during working memory was probed. Functional connectivity with ipsilateral parietal cortex (h 2 =24%), contra--lateral dorsolateral prefrontal cortex (h 2 =36%), posterior cingulate cortex (h 2 =37%) and middle frontal cortex (h 2 =26%) were found to be heritable. However, the connections during baseline condition were also heritable, suggesting the heritability did not pertain to WM--specific connectivity, and connectivity with left hippocampus was not found to be heritable.iii Declaration by authorThis thesis is composed of my original work, and contains no material previously published or written by another person except where due reference has been made in the text. I have clearly stated the contribution by others to jointly--authored works that I have included in my thesis.I have clearly stated the contribution of others to my thesis as a whole, including statistical assistance, survey design, data analysis, significant technical procedures, professional editorial advice, and any other original research work used or reported in my thesis. The content of my thesis is the result of work I have carried out since the commencement of my research higher degree candidature and does not include a substantial part of work that has been submitted to qualify for the award of any other degree or diploma in any university or other tertiary institution. I have clearly stated which parts of my thesis, if any, have been submitted to qualify for another award.I acknowledge that an electronic copy of my thesis must be lodged with the University Library and, subject to the policy...

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Dynamic causal modeling of load-dependent modulation of effective connectivity within the verbal working memory network

Cited by 57 publications

References 41 publications

The effect of binaural beats on verbal working memory and cortical connectivity

The effect of binaural beats on verbal working memory and cortical connectivity

Neuroscience-Informed Cognitive-Affective Training Interventions for Mood and Anxiety Disorders

Genetics of functional brain networks

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