Dynamic changes in reactive oxygen species and antioxidant levels in retinas in experimental glaucoma

Ko, Mei–Lan; Peng, Pai-Huei; Ma, Ming‐Chieh; Ritch, Robert; Chen, Chau-Fong

doi:10.1016/j.freeradbiomed.2005.03.025

Cited by 107 publications

(87 citation statements)

References 39 publications

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“…In their study, Tsang et al (2006) studied visual field in moderate-to-severe obstructive sleep apnoea (OSAS) patients and showed a higher incidence of visual field defects and concluded that optic nerve may be damaged directly by anoxic damage or indirectly by decreased optic nerve head blood flow during recurrent apnoeas. The optic nerve damage and retinal ganglion cell death in glaucoma have been explained by increased reactive oxygen species in hypoxic and hypoperfused tissue (Flammer et al 2002;Ko et al 2005;Yanagi et al 2011). Several studies have shown evidence of decreased vasodilation, increased atherosclerosis, arterial stiffness, risk of cardiovascular disease and abnormalities in systemic vascular function in patients with COPD.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of visual field parameters in patients with chronic obstructive pulmonary disease

Demir

Inonu

Kurt

et al. 2012

Acta Ophthalmologica

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ABSTRACT.Purpose: To evaluate the effects of chronic obstructive pulmonary disease (COPD) on retina and optic nerve. Methods: Thirty-eight patients with COPD and 29 healthy controls, totally 67 subjects, were included in the study. Visual evoked potentials (VEP) and visual field assessment (both standard achromatic perimetry (SAP) and short-wavelength automated perimetry (SWAP)) were performed on each subject after ophthalmological, neurological and pulmonary examinations. Results: Mean deviation (MD), pattern standard deviation (PSD) and corrected pattern standard deviation (CPSD) were significantly different between patient and control groups as for both SAP and SWAP measurements (p = 0.001, 0.019, 0.009 and p = 0.004,0.019, 0.031, respectively). Shortterm fluctuation (SF) was not statistically different between the study and the control groups (p = 0.874 and 0.694, respectively). VEP P100 latencies were significantly different between patients with COPD and the controls (p = 0.019). Conclusion: Chronic obstructive pulmonary disease is a systemic disease, and hypoxia in COPD seems to affect the retina and the optic nerve.

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Section: Discussionmentioning

confidence: 99%

Evaluation of visual field parameters in patients with chronic obstructive pulmonary disease

Demir

Inonu

Kurt

et al. 2012

Acta Ophthalmologica

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“…For example, experimental elevation of IOP in rats using intraocular hyaluronic acid injections has resulted in a significant decrease in retinal antioxidants parallel to a time-dependent increase in retinal lipid peroxidation (Moreno et al, 2004). Another study using the cauterization of episcleral veins to induce IOP elevation has similarly demonstrated amplified ROS generation and increased lipid peroxidation in the ocular hypertensive rat retina (Ko et al, 2005). Our findings using the rat glaucoma model induced by hypertonic saline injections into episcleral veins have also revealed a prominent increase in protein carbonyl immunoreactivity after IOP elevation, which reflects the oxidative modification of proteins .…”

Section: Oxidative Component Of the Glaucomatous Tissue Stressmentioning

confidence: 99%

Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences

Tezel

2006

Progress in Retinal and Eye Research

612

449

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Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. Although ROS are essential participants in cell signaling and regulation, when their cellular production overwhelms the intrinsic antioxidant capacity, damage to cellular macromolecules such as DNA, proteins, and lipids ensues. Such a state of "oxidative stress" is thought to contribute to the pathogenesis of a number of neurodegenerative diseases. Growing evidence supports the involvement of oxidative stress as a common component of glaucomatous neurodegeneration in different subcellular compartments of retinal ganglion cells (RGCs). Besides the evidence of direct cytotoxic consequences leading to RGC death, it also seems highly possible that ROS are involved in signaling RGC death by acting as a second messenger and/or modulating protein function by redox modifications of downstream effectors through enzymatic oxidation of specific amino acid residues. Different studies provide cumulating evidence, which supports the association of ROS with different aspects of the neurodegenerative process. Oxidative protein modifications during glaucomatous neurodegeneration increase neuronal susceptibility to damage and also lead to glial dysfunction. Oxidative stress-induced dysfunction of glial cells may contribute to spreading neuronal damage by secondary degeneration. Oxidative stress also promotes the accumulation of advanced glycation end products in glaucomatous tissues. It is also evident that oxidative stress takes part in the activation of immune response during glaucomatous neurodegeneration, as ROS stimulate the antigen presenting ability of glial cells and also function as co-stimulatory molecules during antigen presentation. By discussing current evidence, this review provides a broad perspective on cellular mechanisms and potential consequences of oxidative stress in glaucoma.

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“…The linkage between oxidative stress and retinal damage in a rat model of glaucoma was recently shown. 31 A recent study evaluated oxidative markers in glaucoma patients' AH. 32 and concluded that oxidative stress may lead to an induction of antioxidant enzymes and contribute to total reactive antioxidant potential (TRAP) decrease.…”

Section: Discussionmentioning

confidence: 99%

Decrease in reducing power of aqueous humor originating from glaucomatous rabbits

Beit‐Yannai

Trembovler

Solomon

2006

Eye

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Aim To evaluate changes in the reducing power of aqueous humor (AH) with cyclic voltammetry (CV) and HPLC-EC. Methods NZW Rabbits exhibiting a sporadic mutation causing bilaterally buphthalmus eyes were set for intra ocular pressure (IOP) and eye size measurements. AH was obtained under anesthesia, from congenital glaucomatic rabbits (CGR, n ¼ 6) and age-matched controls (CON; n ¼ 6). The AH samples were analysed by CV and HPLC-EC. Results CGR IOP was found to be significantly higher than in CON (33.571.1 and 14.271.0 mmHg, respectively), eye size was 18.25 and 13.9 cm, respectively. CV analysis revealed two anodic currents representing two groups of low molecular weight antioxidant (LMWA). The two anodic potentials were equal for the two tested groups, indicating the same components of LMWA. The first anodic current of CGR was only 30% of the CON rabbits (2.11 vs 7.17 lA/mg protein, t-test: Po0.05). As the main hydrophilic components of the first anodic current are known to be uric acid (UA) and ascorbic acid (AA), they were analysed for exact content by HPLC-EC. UA and AA levels were significantly lower in the CGR group (UA: 17.173.2 and 189.1775.70 lM/mg, AA: 1.170.3 and 4.872.0 lM/mg protein respectively). Conclusions Changes in the reducing power, as indicated by CV analysis, of CGR AH, is probably a result of chronic oxidative stress caused by the pathology. The differences in the first anodic wave are mainly due to a fall in the concentration of UA and AA.

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Dynamic changes in reactive oxygen species and antioxidant levels in retinas in experimental glaucoma

Cited by 107 publications

References 39 publications

Evaluation of visual field parameters in patients with chronic obstructive pulmonary disease

Evaluation of visual field parameters in patients with chronic obstructive pulmonary disease

Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences

Decrease in reducing power of aqueous humor originating from glaucomatous rabbits

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