2023
DOI: 10.1186/s41021-023-00278-1
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Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer

Abstract: Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced DNA damage directly, or oxidative stress-related damage, resulting in cell apoptosis and carcinogenesis in human respiratory system, digestive system, reproductive system, etc. Moreover, BaP triggered genome-wide epigenetic alterations by methylation, which might cause disturbances in regulation of gene ex… Show more

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Cited by 9 publications
(3 citation statements)
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“…Humans are exposed via cigarette smoke, roasted or burnt food, polluted air, and via skin exposure to contaminated soil and water [34][35][36][37][38]. Some PAHs, like benzo(a)pyrene, are potent carcinogens [35,39]. PAHs are known ligands of the aryl hydrocarbon receptor.…”
Section: Polyaromatic Hydrocarbonsmentioning
confidence: 99%
“…Humans are exposed via cigarette smoke, roasted or burnt food, polluted air, and via skin exposure to contaminated soil and water [34][35][36][37][38]. Some PAHs, like benzo(a)pyrene, are potent carcinogens [35,39]. PAHs are known ligands of the aryl hydrocarbon receptor.…”
Section: Polyaromatic Hydrocarbonsmentioning
confidence: 99%
“…Meanwhile, BaP is also the earliest and most important carcinogen found in PAHs (Wang et al 2023). To this end, BaP was hereby selected as the representative pollutant of HMW-PAHs for corresponding remediation technology research.…”
Section: Introductionmentioning
confidence: 99%
“…DNA methylation is an important mechanism of chromatin conformation change lying at the heart of gene expression regulation and occurs in specific highly conserved sites -CpG islands located at the 5′ end of protein gene coding regions [15,23]. For example, benzaprene, one of the first investigated and studied carcinogens from the polycyclic aromatic hydrocarbon family, can induce the onset of cancer through inhibition of methylation processes near the promoter regions of tumor suppressor genes [23,24].…”
Section: Introductionmentioning
confidence: 99%