In order to comprehensively improve the ride comfort performance and the road friendliness performance of the heavy vehicles, an inertial suspension using ground-hook (GH) control is proposed in this paper, and the suspension performances are compared at different loading rates and driving speeds. Firstly, a half vehicle model of the inertial suspension of the heavy vehicle based on the GH control is established. Then, the key parameters of the GH inertial suspension are optimized by the genetic algorithm and the system simulations are carried out. By comparing to the conventional passive suspension, the root-mean-square (RMS) of the vertical acceleration of the body centroid is reduced by 4.87%, and the RMS of the dynamic tire loads of the front and the rear wheels are reduced by 16.19% and 10.02%, respectively. Results show that the GH inertial suspension can effectively coordinate and improve the ride comfort and road friendliness of heavy vehicles simultaneously.