The rapid development of digital tools for crop management offers new opportunities to mitigate the effects of climate change on agriculture. This study examines the Normalized Difference Vegetation Index (NDVI) in coffee-growing areas of the province of Rodriguez de Mendoza, southern Peru, from 2001 to 2022. The objectives were the following: (a) to analyze NDVI trends in these areas; (b) to investigate trends in climatic variables and their correlations with altitude and NDVI; and c) to develop linear models tailored to each coffee-growing area. The study identified significant differences in NDVI trends among coffee plants, with mean NDVI values ranging from about 0.6 to 0.8. These values suggest the presence of stress conditions that should be monitored to improve crop quality, particularly in Huambo. Variability in rainfall, maximum and minimum temperatures, relative humidity, and altitude was also observed, with NDVI values showing a strong negative correlation with altitude. These results are crucial for making informed strategic decisions in integrated crop management and for monitoring crop health using vegetation indices.