Dynamic chromatin accessibility landscapes of osteoblast differentiation and mineralization

Chen, Yueqi; Tan, Jiulin; Yang, Chuan; Ling, Zhiguo; Xu, Jianzhong; Sun, Dong; Luo, Fei

doi:10.1016/j.bbadis.2023.166938

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…Fecal pellets (5)(6)(7)(8) were delicately collected into individual sterile tubes and swiftly fixed upon the dry ice ensuring immediate preservation of their microbial content. Subsequently, fecal specimens were immediately stored at a frigid temperature of −80°C until analysis.…”

Section: Fecal 16s Rdna Gene Sequencingmentioning

confidence: 99%

“…[4][5][6] At the cellular level, this imbalance is manifested in the activity disorder of osteoclasts (OCs) and osteoblasts (OBs). [7][8][9] OCs are multinucleated giant cells formed by the fusion of monocytic precursors in the presence of macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B ligand (RANKL). 10 OCs attach tightly to bone surface and gobble up bone mass by excreting H + and protease, which achieve bone remodeling via coordination with OB-mediated bone formation.…”

Section: Introductionmentioning

confidence: 99%

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Gut microbially produced tryptophan metabolite melatonin ameliorates osteoporosis via modulating SCFA and TMAO metabolism

Chen,

Yang,

Deng

et al. 2024

Journal of Pineal Research

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Osteoporosis (OP) is a severe global health issue that has significant implications for productivity and human lifespan. Gut microbiota dysbiosis has been demonstrated to be closely associated with OP progression. Melatonin (MLT) is an important endogenous hormone that modulates bone metabolism, maintains bone homeostasis, and improves OP progression. Multiple studies indicated that MLT participates in the regulation of intestinal microbiota and gut barrier function. However, the promising effects of gut microbiota‐derived MLT in OP remain unclear. Here, we found that OP resulted in intestinal tryptophan disorder and decreased the production of gut microbiota‐derived MLT, while administration with MLT could mitigate OP‐related clinical symptoms and reverse gut microbiota dysbiosis, including the diversity of intestinal microbiota, the relative abundance of many probiotics such as Allobaculum and Parasutterella, and metabolic function of intestinal flora such as amino acid metabolism, nucleotide metabolism, and energy metabolism. Notably, MLT significantly increased the production of short‐chain fatty acids and decreased trimethylamine N‐oxide‐related metabolites. Importantly, MLT could modulate the dynamic balance of M1/M2 macrophages, reduce the serum levels of pro‐inflammatory cytokines, and restore gut‐barrier function. Taken together, our results highlighted the important roles of gut microbially derived MLT in OP progression via the “gut‐bone” axis associated with SCFA metabolism, which may provide novel insight into the development of MLT as a promising drug for treating OP.

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Section: Fecal 16s Rdna Gene Sequencingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gut microbially produced tryptophan metabolite melatonin ameliorates osteoporosis via modulating SCFA and TMAO metabolism

Chen,

Yang,

Deng

et al. 2024

Journal of Pineal Research

Self Cite

View full text Add to dashboard Cite

show abstract

Krüppel‐like factors family in health and disease

Xiang,

Yang,

Deng

et al. 2024

MedComm

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Krüppel‐like factors (KLFs) are a family of basic transcription factors with three conserved Cys2/His2 zinc finger domains located in their C‐terminal regions. It is acknowledged that KLFs exert complicated effects on cell proliferation, differentiation, survival, and responses to stimuli. Dysregulation of KLFs is associated with a range of diseases including cardiovascular disorders, metabolic diseases, autoimmune conditions, cancer, and neurodegenerative diseases. Their multidimensional roles in modulating critical pathways underscore the significance in both physiological and pathological contexts. Recent research also emphasizes their crucial involvement and complex interplay in the skeletal system. Despite the substantial progress in understanding KLFs and their roles in various cellular processes, several research gaps remain. Here, we elucidated the multifaceted capabilities of KLFs on body health and diseases via various compliable signaling pathways. The associations between KLFs and cellular energy metabolism and epigenetic modification during bone reconstruction have also been summarized. This review helps us better understand the coupling effects and their pivotal functions in multiple systems and detailed mechanisms of bone remodeling and develop potential therapeutic strategies for the clinical treatment of pathological diseases by targeting the KLF family.

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Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation

Su,

Cui,

Zhou

et al. 2024

Sci Rep

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Dynamic chromatin accessibility landscapes of osteoblast differentiation and mineralization

Cited by 3 publications

References 45 publications

Gut microbially produced tryptophan metabolite melatonin ameliorates osteoporosis via modulating SCFA and TMAO metabolism

Gut microbially produced tryptophan metabolite melatonin ameliorates osteoporosis via modulating SCFA and TMAO metabolism

Krüppel‐like factors family in health and disease

Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation

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