2001
DOI: 10.1103/physrevlett.87.278102
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Dynamic Compartmentalization of Bacteria: Accurate Division inE. Coli

Abstract: Positioning of the midcell division plane within the bacterium E. coli is controlled by the min system of proteins: MinC, MinD and MinE. These proteins coherently oscillate from end to end of the bacterium. We present a reaction-diffusion model describing the diffusion of min proteins along the bacterium and their transfer between the cytoplasmic membrane and cytoplasm. Our model spontaneously generates protein oscillations in good agreement with experiments. We explore the oscillation stability, frequency and… Show more

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Cited by 176 publications
(218 citation statements)
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“…Because the motors on both ends are presumed to be genetically and chemically identical, this process is likely controlled by a spatial chemical oscillator inside the cell, e.g., periodic assembly or disassembly of mesh-like structures at the cell poles. Similar structures are associated with the location of the division plane in enteric bacteria (the Min system oscillator) (47)(48)(49)(50)(51)(52). Various models for these patterns have been constructed based on Turing instability reactiondiffusion patterns (48,52).…”
Section: Discussionmentioning
confidence: 89%
“…Because the motors on both ends are presumed to be genetically and chemically identical, this process is likely controlled by a spatial chemical oscillator inside the cell, e.g., periodic assembly or disassembly of mesh-like structures at the cell poles. Similar structures are associated with the location of the division plane in enteric bacteria (the Min system oscillator) (47)(48)(49)(50)(51)(52). Various models for these patterns have been constructed based on Turing instability reactiondiffusion patterns (48,52).…”
Section: Discussionmentioning
confidence: 89%
“…This model is somewhat related to the treadmilling of microtubules; however, the difference is that nucleotide hydrolysis is activated using an external factor (Spo0J). If polymerization and depolymerization are cooperative, then a pattern will form with waves of proteins oscillating and this can be modelled in silico (Howard et al 2001;Hunding et al 2003;. The time-averaged result is a concentration gradient that can be used to obtain positional information, as has been predicted for the MinCDE system.…”
Section: Speculation: Spo0j-assisted Treadmilling Of Sojmentioning
confidence: 99%
“…43 As for the membrane diffusion constants, we have used similarly small values to those used in E. coli. 24,27 Previously this was an important component in the spontaneous reactiondiffusion instability; this is, however, not the case here: the small membrane diffusivities are now necessary to preserve the polar density concentration maxima and to prevent the concentrations from equalizing everywhere along the cell membrane. For the remaining parameters there is no experimental guidance, but we have taken care to check that our results are robust to variations in these parameters.…”
Section: The Modelmentioning
confidence: 99%
“…This is again similar to some of the models used for E. coli. 24,26,27 The relevant set of one-dimensional reaction-diffusion equations are:…”
Section: The Modelmentioning
confidence: 99%