Dynamic contrast enhanced magnetic resonance imaging of the terminal ileum: differentiation of activity of Crohn’s disease

Vescovo, Riccardo Del; Sansoni, Ilaria; Caviglia, Renato; Ribolsi, Mentore; Perrone, Giuseppe; Leoncini, Emanuele; Grasso, Rosario Francesco; Cicala, Michele; Zobel, Bruno Beomonte

doi:10.1007/s00261-007-9267-4

Cited by 110 publications

(68 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have also shown that the MRI technique defines not only the site but also the degree of CD activity, by evaluating the increased enhancement of the involved bowel wall by means of contrast T1-weighted sequences. [6][7][8][9][10][11][12] Horsthuis et al performed a meta-analysis and reported that there was no statistically significant difference between MRI and CT in the detection of inflammatory bowel disease, including extra-enteric complications. 13 The retroperitoneal abscess is a relatively rare condition and is often misdiagnosed or even recognized late in the clinical course.…”

Section: Consentmentioning

confidence: 99%

Fistulizing Crohn’s Disease Complicated by Hidden Retroperitoneal Abscess: A Case Report and Review of the Literature

Caviglia¹,

Castro²,

Cannaviello³

et al. 2015

Gastro Open J

Self Cite

View full text Add to dashboard Cite

Crohn's Disease (CD) is a chronic inflammatory disorder of the intestinal tract characterized by trans-mural damage of the bowel wall often complicated by strictures, entero-visceral and perianal fistulae and abscesses. Both computed tomography and magnetic resonance enable clear visualization of the involved intestinal tract together with various extra-and intraintestinal complications. Herewith, the uncommon case of a hidden retroperitoneal abscess with para-vertebral collection, as a consequence of a penetrating CD of the terminal ileum, is described. Retrofascial collections, due to fistulizing CD, are rare events often misdiagnosed or even recognized late in the clinical course and associated with severe and potentially lifethreatening consequences. Prompt assessment with cross-sectional imaging is necessary. MR imaging is being more frequently used in the follow-up of CD since the lack of ionizing radiations which avoids any biological impact in these patients. CAsE REPoRtA 30-year-old female with a 3-year history of Crohn's Disease (CD) of the terminal ileum and complaining recently of a 3-week progressive abdominal pain, nausea and diarrhea (5-6 bowel movements/day) was admitted to the hospital. The patient was febrile (37.5 °C) and presented right lumbar pain radiating to the gluteus region. The patient had been treated with methotrexate, mesalazine and metronidazole over the previous 6 months.Upon presentation, the abdominal examination revealed normal bowel sounds and abdominal tenderness without rebound. A mass, 7 cm by 3 cm, was palpated in the lower right quadrant, which was tender to palpation, without guarding, rebound or tap tenderness. The remainder of the examination was normal. Blood tests showed moderate leucocytosis and an increase both in Erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP) levels

show abstract

Section: Consentmentioning

confidence: 99%

Fistulizing Crohn’s Disease Complicated by Hidden Retroperitoneal Abscess: A Case Report and Review of the Literature

Caviglia¹,

Castro²,

Cannaviello³

et al. 2015

Gastro Open J

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several later studies emphasized the usefulness of MR in distinguishing patients with active disease from those with inactive disease (4)(5)(6)(7)(8)(9)(10). However, the current issue is whether MRI is able to grade the severity of the disease in the same way as other techniques.…”

Section: Introductionmentioning

confidence: 99%

Ileal Crohn's disease: MRI with endoscopic correlation

Gallego

Echarri

Porta

et al. 2011

European Journal of Radiology

View full text Add to dashboard Cite

Purpose: To evaluate activity staging of Crohn's disease (CD) measured with MRenterography using ileoscopy as reference standard. Materials and methods: A prospective study was made of 61 patients with CD. All patients underwent MR-enterography and ileoscopy. MRI activity was measured by means of an ad hoc developed score, as well as by analysis of the imaging findings, and was compared with the SES-CD score obtained via ileoscopy. Examinations were performed using a 1.0 Tesla scanner. Results: MRI score discriminates between active and inactive disease with an area under the ROC curve of 0.941. Overall correlation with the standard reference SES-CD score was moderate to strong (Spearman's r=0.62 p<0.001). Agreement between both methods in staging patients with ileal CD as inactive, mild or moderate to severe was good (Cohen's κ=0.60). Differences in means of the MRI activity scores of the three groups showed statistical significance (p<0.01). Conclusions: The MRI score is a reliable predictor of activity in ileal CD and can stage patients in a way comparable to endoscopy. 1.0 Tesla scans are valid for performing radiological evaluation of ileal Crohn's disease. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 Agreement between both methods in staging patients with ileal CD as inactive, mild or moderate to severe was good (Cohen's κ=0.60). Differences in means of the MRI activity scores of the three groups showed statistical significance (p<0.01).Conclusions: The MRI score is a reliable predictor of activity in ileal CD and can stage patients in a way comparable to endoscopy. 1.0 Tesla scans are valid for performing radiological evaluation of ileal Crohn's disease.

show abstract

“…Meanwhile, other studies have demonstrated a correlation between MRE and CDAI (33,46,47) and a correlation between MRE and laboratory markers of inflammation (erythrocyte sedimentation rate/C-reactive protein) (41-43). Only two pediatric studies compared MRE to PCDAI, one demonstrating a statistically significant correlation between disease on MRE and PCDAI (48) and the other demonstrating no correlation between MRE and PCDAI (49).…”

Section: Comparison Of Mre To Disease Activity Indexmentioning

confidence: 99%

Magnetic resonance enterography in crohn’s disease: techniques, interpretation, and utilization for clinical management

Martín

Kalb

Sauer

et al. 2011

Diagn Interv Radiol

View full text Add to dashboard Cite

Dynamic contrast enhanced magnetic resonance imaging of the terminal ileum: differentiation of activity of Crohn’s disease

Abstract: D-CE-MRI can be a useful tool for clinical follow-up and in the treatment strategies in CD patients.

Cited by 110 publications

References 21 publications

Fistulizing Crohn’s Disease Complicated by Hidden Retroperitoneal Abscess: A Case Report and Review of the Literature

Fistulizing Crohn’s Disease Complicated by Hidden Retroperitoneal Abscess: A Case Report and Review of the Literature

Ileal Crohn's disease: MRI with endoscopic correlation

Magnetic resonance enterography in crohn’s disease: techniques, interpretation, and utilization for clinical management

Contact Info

Product

Resources

About