Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients

Chen, Bang-Bin; Hsu, Chih-Wei; Yu, Chih‐Wei; Wei, Shih-Chung; Kao, Jia‐Horng; Lee, Hsuan-Shu; Shih, Tiffany Ting-Fang

doi:10.1007/s00330-011-2249-5

Cited by 98 publications

(99 citation statements)

References 36 publications

(43 reference statements)

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“…These studies also provided hepatic function maps to depict the anatomic distribution of hepatic function. A more recent study adopting a dual-input single compartment model suggested that the arterial blood flow was a good predictor for mild fibrosis [44]. …”

Section: Hepatic Function From Hepatic Parenchymal Enhancementmentioning

confidence: 99%

Assessment of Hepatic Function with Gd-EOB-DTPA-Enhanced Hepatic MRI

Bae

Kim²,

Lee³

et al. 2012

Dig Dis

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Assessment of hepatic function is essential in determining the prognosis and clinical management of a patient who has chronic liver disease or undergoes liver surgery. For a patient with locally varying hepatic parenchymal abnormalities, a regional assessment of hepatic function mapped onto hepatic anatomy is clinically more meaningful than conventional global metrics of hepatic function. Of late, hepatic magnetic resonance imaging has been increasingly used because of its superb tissue contrast and delineation of hepatic morphology and underlying abnormalities. The introduction of hepatocyte-specific contrast agents such as Gd-EOB-DTPA allows us to view not only the hepatic anatomy but also assess regional hepatic function. In this article, we review and discuss recently published studies that used Gd-EOB-DTPA-enhanced magnetic resonance imaging to evaluate hepatic function.

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Section: Hepatic Function From Hepatic Parenchymal Enhancementmentioning

confidence: 99%

Assessment of Hepatic Function with Gd-EOB-DTPA-Enhanced Hepatic MRI

Bae

Kim²,

Lee³

et al. 2012

Dig Dis

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“…Chen et al performed a prospective study using Gd-EOB-DTPA in patients with chronic hepatitis to calculate perfusion parameters by applying a dual-input single compartment model. They found a significant increase in arterial perfusion at 60 s and 100 s in patients compared with healthy subjects and a significant difference in arterial perfusion when three different fibrotic subgroups (none, mild and advanced) were compared at 60 s [113].…”

Section: Mr Elastographymentioning

confidence: 98%

Radiologic Assessment of Liver Fibrosis – Present and Future

Macarini¹,

Stoppino²

2013

Practical Management of Chronic Viral Hepatitis

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“…In terms of diagnosis, malignant liver tumors have been reported to have high perfusion values (high blood flow, high blood volume, high permeability, and low mean transit time) compared with normal tissue [11,12]. In terms of treatment monitoring, HCCs show a fall in blood flow, blood volume, and permeability after antiangiogenic treatment or chemoembolization [13,14].…”

Section: Perfusion Imagingmentioning

confidence: 99%

“…In addition, new contrast agents and elastography are now being developed to increase the effectiveness of detection and characterization of tumors [3,11]. Furthermore, research into functional imaging such as perfusion imaging with CT or MRI, diffusion-weighted imaging (DWI), and elastography is making progress [12][13][14][15][16]. These techniques seem to have strong potential to improve detection and characterization of HCC [17,18].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in CT and MR Imaging for Evaluation of Hepatocellular Carcinoma

et al. 2012

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Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Accurate diagnosis and assessment of disease extent are crucial for proper management of patients with HCC. Imaging plays a crucial role in early detection, accurate staging, and the planning of management strategies. A variety of imaging modalities are currently used in evaluating patients with suspected HCC; these include ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine, and angiography. Among these modalities, dynamic MRI and CT are regarded as the best imaging techniques available for the noninvasive diagnosis of HCC. Recent improvements in CT and MRI technology have made noninvasive and reliable diagnostic assessment of hepatocellular nodules possible in the cirrhotic liver, and biopsy is frequently not required prior to treatment. Until now, the major challenge for radiologists in imaging cirrhosis has been the characterization of small cirrhotic nodules smaller than 2 cm in diameter. Further technological advancement will undoubtedly have a major impact on liver tumor imaging. The increased speed of data acquisition in CT and MRI has allowed improvements in both spatial and temporal resolution, which have made possible a more precise evaluation of the hemodynamics of liver nodules. Furthermore, the development of new, tissue-specific contrast agents such as gadoxetic acid has improved HCC detection on MRI. In this review, we discuss the role of CT and MRI in the diagnosis and staging of HCC, recent technological advances, and the strengths and limitations of these imaging modalities.

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Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients

Abstract: DCE-MRI with Gd-EOB-DTPA is a noninvasive imaging, by which multiple perfusion parameters can be measured to evaluate the severity of liver fibrosis.

Cited by 98 publications

References 36 publications

Assessment of Hepatic Function with Gd-EOB-DTPA-Enhanced Hepatic MRI

Assessment of Hepatic Function with Gd-EOB-DTPA-Enhanced Hepatic MRI

Radiologic Assessment of Liver Fibrosis – Present and Future

Recent Advances in CT and MR Imaging for Evaluation of Hepatocellular Carcinoma

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