Dynamic contrast‐enhanced MR imaging of musculoskeletal tumors: Basic principles and clinical applications

Verstraete, Koenraad; Woude, Henk-Jan van der; Hogendoorn, Pancras C.W.; Deene, Yves De; Kunnen, Marc; Bloem, J. L.

doi:10.1002/jmri.1880060210

Cited by 135 publications

(66 citation statements)

References 51 publications

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“…1), digestive system (Supplemental Fig. 2),et al, 2012) and some bone tumors (Verstraete et al, 1996;Wenger and Wold, 2000) are well perfused. By extension, the same principle holds for cancer cells undergoing metastasis, which occurs mainly via the circulation (van Zijl et al, 2011).…”

Section: A Curcumin Pharmacokinetics and Pharmacodynamicsmentioning

confidence: 91%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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Section: A Curcumin Pharmacokinetics and Pharmacodynamicsmentioning

confidence: 91%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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“…5 Objective evaluation of tumor vascularity can be accomplished by creating TICs and measuring the pharmacokinetics of the contrast agent during and immediately after the first pass. 7 Various perfusion indices can be derived from these data, such as time of onset of enhancement, wash-in slope, washout slope, time-to-peak, and peak enhancement signal percentage change. Many have studied the possibility of unique TICs for different pathologies, but conclusions have been equivocal, partly due to assumptions of homogeneity within the lesions.…”

mentioning

confidence: 99%

Characterizing Hypervascular and Hypovascular Metastases and Normal Bone Marrow of the Spine Using Dynamic Contrast-Enhanced MR Imaging

Khadem¹,

Karimi²,

Peck³

et al. 2012

AJNR Am J Neuroradiol

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“…37 Once cystic, lipomatous, and vascular lesions have been ruled out, it is estimated that the ability of MRI to accurately characterize lesions is low, often ,50%. [38][39][40][41] Patterns of contrast enhancement in benign and malignant lesions overlap, 38 and with DCE-MRI malignant lesions typically demonstrate rapid early arterial enhancement and higher slopes of enhancement compared with benign lesions, 15,[17][18][19] but this pattern is not entirely specific (Fig 3). Finally, MRS is an emerging technique that has recently been applied to the characterization of musculoskeletal tumors.…”

Section: Figurementioning

confidence: 99%

De Novo Assessment of Pediatric Musculoskeletal Soft Tissue Tumors: Beyond Anatomic Imaging

Ahlawat

Fayad

2015

Pediatrics

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MRI plays a central role in the assessment of pediatric musculoskeletal soft tissue tumors. Although these neoplasms may initially be evaluated on other modalities, such as sonography, MRI is essential for accurately determining the extent of disease. Traditionally, MRI has been performed with sequences that provide excellent anatomic detail, with T1-weighted, fluid-sensitive, and static postcontrast T1-weighted sequences. However, with the introduction of noncontrast sequences such as diffusion-weighted imaging and magnetic resonance spectroscopy to the arsenal of available MRI techniques, functional and metabolic features of a neoplasm can now be examined noninvasively. These more recent MRI methods offer information for lesion characterization, the assessment of treatment response, and the distinction of postoperative scar from recurrence. Dynamic contrast-enhanced perfusion imaging is another useful functional technique that can be acquired before conventional static postcontrast imaging, without requiring additional contrast material. This review presents recent advances in MRI methodology that enable a comprehensive clinical assessment of musculoskeletal tumors in the pediatric population. The roles and challenges of combining anatomic, functional, and metabolic MRI sequences will be discussed as they relate to newly discovered soft tissue tumors in children.A principal role for MRI in the evaluation of pediatric musculoskeletal tumors is the determination of extent of disease for appropriate preoperative planning. Diffusion-weighted imaging (DWI), dynamic contrast-enhanced perfusion imaging (DCE-MRI), and magnetic resonance spectroscopy (MRS) have expanded the role of MRI to include lesion characterization, treatment response, and the detection of postsurgical recurrence. In this review, conventional (anatomic sequences) and advanced (functional and metabolic sequences) imaging will be discussed, with an emphasis on how these sequences are used in the clinical setting of newly discovered (de novo) pediatric soft tissue tumors. The assessment of treatment response and postsurgical recurrence is beyond the scope of this article. CHALLENGES IN THE PEDIATRIC PATIENTPediatric imaging presents unique challenges that are not encountered in the adult setting. The need for sedation in young children requires that a comprehensive protocol also be succinct. A complete tumor protocol that includes anatomic, functional, and metabolic sequences has been previously described. 1 The examination requires 60 minutes, with 15 minutes of this time allotted to MRS if desired (see Table 1).Additional challenges encountered in pediatric patients include their small size with resultant decreased signal and inherently low scan resolution.

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Dynamic contrast‐enhanced MR imaging of musculoskeletal tumors: Basic principles and clinical applications

Cited by 135 publications

References 51 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Characterizing Hypervascular and Hypovascular Metastases and Normal Bone Marrow of the Spine Using Dynamic Contrast-Enhanced MR Imaging

De Novo Assessment of Pediatric Musculoskeletal Soft Tissue Tumors: Beyond Anatomic Imaging

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