Dynamic contrast-enhanced MRI of implanted VX2 tumors in rabbit muscle: comparison of Gd-DTPA and NMS60

Comparison between intravenous and intraarterial contrast injections for dynamic 3D MRI of liver tumors in the VX2 rabbit model

“…Further studies are necessary to determine whether a conventional single-or multiphase 2D GRE imaging strategy could be utilized for breath-held acquisition following an appropriate delay (ϳ30 seconds) after IA contrast injection. The time interval between IV injection and peak CNR correlated well with previous CE studies in the VX2 rabbit tumor model, which demonstrated peak enhancement at roughly one minute post-injection (14,23).…”

A Comparison of CH3-DTPA-GD (NMS60) and GD-DTPA for Evaluation of Acute Myocardial Ischemia

“…In reperfused lesions, the larger molecular size of NMS60 may also increase the dynamic range of vascular permeability measurements (as suggested in an earlier tumor study) and aid in characterization of infarcted myocardium and delayed contrast enhancement. There is also the added advantage of the lower toxicity of NMS60 which will allow for multiple injections [33].…”

“…This agent has a higher relaxivity and longer vascular retention time than Gd-DTPA, but with lower toxicity when compared to Gd-DTPA or other macromolecular contrast agents. NMS60 has shown efficacy for 3D MRA and in dynamic MRI of tumors in experimental models [32,33].…”

Superior Vena Cava Doppler Flow Changes in Superior Vena Cava Syndrome

“…An animal SVC obstruction model would be of use in further studies directed at optimizing the therapeutic strategies for original tumors causing SVC syndrome in patients, yet no detailed information about the establishment of an animal SVC obstruction (SVCO) model can be found in the literature. It has been reported that VX2 tumor cell could be successfully inoculated into multiple organs to induce malignant tumors in rabbits (De Crespigny et al, 1999;Goldberg et al, 1999;Ishida et al, 2000), and various imaging modalities has been adopted to assess the effect of this inoculation (Kim et al, 2000;Liu et al, 2001). We hypothesize that a rabbit model with SVCO could be established by inoculating VX2 tumors cells into the areas around the SVC.…”