Dynamic Contrast-Enhanced Ultrasonography with Sonazoid for Diagnosis of Microvascular Invasion in Hepatocellular Carcinoma

Li, Xintong; Han, Xue; Li, Lei; Su, Chang; Sun, Juan; Zhan, Cheng; Feng, Di; Cheng, Wen

doi:10.1016/j.ultrasmedbio.2021.11.005

Cited by 21 publications

(9 citation statements)

References 27 publications

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“…First, this study is a single‐center study with a small number of cases, and our results are slightly different from those from other multi‐center large sample size studies. AFP has been considered a meaningful parameter in previous studies, and some scholars believe that tumor internal necrosis is related to MVI 14 . However, AFP and tumor internal necrosis in this study demonstrated no statistical significance in the univariate analysis, which may be a negative result caused by an insufficient sample size.…”

Section: Discussioncontrasting

confidence: 65%

“…AFP has been considered a meaningful parameter in previous studies, and some scholars believe that tumor internal necrosis is related to MVI. 14 However, AFP and tumor internal necrosis in this study demonstrated no statistical significance in the univariate analysis, which may be a negative result caused by an insufficient sample size. In the follow-up study, we will continue to collect HCC cases in strict accordance with the inclusion criteria to expand the sample size and include research parameters to improve the accuracy of statistical analysis.…”

Section: Discussioncontrasting

confidence: 59%

“…This examination is simple and time‐saving, suitable for bedside and intraoperative operation. Previous studies have shown that CEUS information can be extracted to predict MVI in HCC 13,14 . However, few studies have made efforts to predict MVI of HCC using the image features of CEUS combined with the dynamic CEUS time‐intensity curve (TIC).…”

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confidence: 99%

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Preoperative Contrast‐Enhanced Ultrasound Predicts Microvascular Invasion in Hepatocellular Carcinoma as Accurately as Contrast‐Enhanced MR

Wang,

Zhang,

Sun

et al. 2023

J of Ultrasound Medicine

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ObjectivesBoth contrast‐enhanced ultrasound (CEUS) and contrast‐enhanced magnetic resonance (CEMR) are important imaging methods for hepatocellular carcinoma (HCC). This study aimed to establish a model using preoperative CEUS parameters to predict microvascular invasion (MVI) in HCC, and compare its predictive efficiency with that of CEMR model.MethodsA total of 93 patients with HCC (39 cases in MVI positive group and 54 cases in MVI negative group) who underwent surgery in our hospital from January 2020 to June 2021 were retrospectively analyzed. Their clinical and imaging data were collected to establish CEUS and CEMR models for predicting MVI. The predictive efficiencies of both models were compared.ResultsBy the univariate and multivariate regression analyses of patients' clinical information, preoperative CEUS static and dynamic images, we found that serrated edge and time to peak were independent predictors of MVI. The CEUS prediction model achieved a sensitivity of 92.3%, a specificity of 83.3%, and an accuracy of 84.6% (Az: 0.934). By analyzing the clinical and CEMR information, we found that tumor morphology, fast‐in and fast‐out, peritumoral enhancement, and capsule were independent predictors of MVI. The CEMR prediction model achieved a sensitivity of 97.4%, a specificity of 77.8%, and an accuracy of 83.2% (Az: 0.900). The combination of the two models achieved a sensitivity of 84.6%, a specificity of 87.0%, and an accuracy of 86.2% (Az: 0.884). There was no significant statistical difference in the areas under the ROC curve of the three models.ConclusionThe CEUS model and the CEMR model have similar predictive efficiencies for MVI of HCC. CEUS is also an effective method to predict MVI before operation.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussioncontrasting

confidence: 59%

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Preoperative Contrast‐Enhanced Ultrasound Predicts Microvascular Invasion in Hepatocellular Carcinoma as Accurately as Contrast‐Enhanced MR

Wang,

Zhang,

Sun

et al. 2023

J of Ultrasound Medicine

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“…There are partially contradictory data regarding the evaluation of inflammatory activity and response to biologic therapy in inflammatory bowel disease [25,26,27,28,29,30,31,32,33,34]. A relatively new field of research is the application of DCE-US for the differential diagnosis, grading of the biological behavior, and outcome assessment of malignant tumors [35,36,37,38,39,40,41]. This position paper is focused on the assessment of tumor perfusion.…”

Section: Why Do We Need Quantification?mentioning

confidence: 99%

EFSUMB Technical Review – Update 2023: Dynamic Contrast-Enhanced Ultrasound (DCE-CEUS) for the Quantification of Tumor Perfusion

Dietrich,

Correas,

Cui

et al. 2023

Ultraschall Med

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Dynamic contrast-enhanced ultrasound (DCE-US) is a technique to quantify tissue perfusion based on phase-specific enhancement after the injection of microbubble contrast agents for diagnostic ultrasound. The guidelines of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) published in 2004 and updated in 2008, 2011, and 2020 focused on the use of contrast-enhanced ultrasound (CEUS), including essential technical requirements, training, investigational procedures and steps, guidance regarding image interpretation, established and recommended clinical indications, and safety considerations. However, the quantification of phase-specific enhancement patterns acquired with ultrasound contrast agents (UCAs) is not discussed here. The purpose of this EFSUMB Technical Review is to further establish a basis for the standardization of DCE-US focusing on treatment monitoring in oncology. It provides some recommendations and descriptions as to how to quantify dynamic ultrasound contrast enhancement, and technical explanations for the analysis of time-intensity curves (TICs). This update of the 2012 EFSUMB introduction to DCE-US includes clinical aspects for data collection, analysis, and interpretation that have emerged from recent studies. The current study not only aims to support future work in this research field but also to facilitate a transition to clinical routine use of DCE-US.

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“…CEUS technology is widely used in focal liver lesions, which makes clear imaging of atypical focal liver lesions that are difficult to detect by CUS (but also nodules that are not clear by CT and MRI), and higher stages of characterization and detection of malignant tumors [16]. Surprisingly, CEUS has also made great achievements in pathological correlation analysis as well as a local assessment after tumor percutaneous ablation and transarterial chemoembolization [17][18][19]. The European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) guidelines recommend that the CEUS process be divided into three phases, including the arterial phase, the portal venous phase, and the delayed phase.…”

Section: Ceus Performance In Hccmentioning

confidence: 99%

Contrast-enhanced ultrasound demonstrates greater adjuvant potential: past, current status, and future applications in Hepatocellular carcinoma early diagnosis

NIE

Wang

et al. 2023

Med Ultrason

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Hepatocellular carcinoma (HCC) has an atypical onset of clinical symptoms and a rapid tumor progression. The majority of patients with HCC are already in the late stages of the disease when they are diagnosed, limiting them to the best available treatments. Contrast-enhanced ultrasound (CEUS) has achieved significant advances in the diagnosis of HCC, including the detection of small lesions, the investigation of more beneficial contrast agents, and the use of CEUS-based radiomics. The purpose of this review is to discuss the relevant research and future challenges of CEUS in the early detection of HCC, to advise more accurate therapy.

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Dynamic Contrast-Enhanced Ultrasonography with Sonazoid for Diagnosis of Microvascular Invasion in Hepatocellular Carcinoma

Cited by 21 publications

References 27 publications

Preoperative Contrast‐Enhanced Ultrasound Predicts Microvascular Invasion in Hepatocellular Carcinoma as Accurately as Contrast‐Enhanced MR

Preoperative Contrast‐Enhanced Ultrasound Predicts Microvascular Invasion in Hepatocellular Carcinoma as Accurately as Contrast‐Enhanced MR

EFSUMB Technical Review – Update 2023: Dynamic Contrast-Enhanced Ultrasound (DCE-CEUS) for the Quantification of Tumor Perfusion

Contrast-enhanced ultrasound demonstrates greater adjuvant potential: past, current status, and future applications in Hepatocellular carcinoma early diagnosis

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