Dynamic contrast enhanced ultrasound for therapy monitoring

Hudson, John M.; Williams, Ronald J.; Tremblay-Darveau, Charles; Sheeran, Paul S.; Milot, Laurent; Bjarnason, Georg A.; Burns, Peter N.

doi:10.1016/j.ejrad.2015.05.013

Cited by 65 publications

(57 citation statements)

References 48 publications

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“…In particular, the apparent difference in sensitivity between FMISO and pimonidazole between the longitudinal studies likely reflects differences in animal number at each time point, with fewer animals analyzed by histology (n = 3/group/time point) than imaging (n = 5/group/time point). Additionally, multiparametric analysis of vascular delivery ( via dynamic contrast enhanced MRI [29-30] or contrast enhanced ultrasound [31-32]) could potentially be informative to simultaneously evaluate the correlations and longitudinal effects of oxygenation (hypoxia) and vascularity. Another limitation of this study is the low uptake of [ 18 F]-FMISO compared to normal tissue, though we do note that the SUV values reported for other xenograft models range from 0.06 to 1.2 [24-25], which is consistent with our study.…”

Section: Discussionmentioning

confidence: 99%

Quantitative [18F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer

et al. 2016

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Purpose Evaluation of [18F]-FMISO-PET imaging as a metric for evaluating early response to trastuzumab therapy with histological validation in a murine model of HER2+ breast cancer. Procedures Mice with BT474, HER2+ tumors, were imaged with [18F]-FMISO-PET during trastuzumab therapy. Pimonidazole staining was used to confirm hypoxia from imaging. Results [18F]-FMISO-PET indicated significant decreases in hypoxia beginning on day 3 (P < 0.01) prior to changes in tumor size. These results were confirmed with pimonidazole staining on day 7 (P < 0.01); additionally, there was a significant positive linear correlation between histology and PET imaging (r2=0.85). Conclusions [18F]-FMISO-PET is a clinically relevant modality which provides the opportunity to 1) predict response to HER2+ therapy before changes in tumor size, and 2) identify decreases hypoxia which has the potential to guide subsequent therapy.

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Section: Discussionmentioning

confidence: 99%

Quantitative [18F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer

et al. 2016

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“…Future studies of respiratory motion could also simulate 3D DCEUS acquisitions to investigate the effect of respiratory motion compensation schemes on DCEUS quantification. However 3D DCEUS is not currently used routinely in the clinic [33] thus there are not enough clinical data available to construct such a model. Both the perfusion and respiration kinetics of the RMSM were derived from clinical dual contrast imaging acquisitions in an effort to maximize the clinical relevance of the model.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Accuracy of Liver Lesion DCEUS Quantification With Respiratory Gating

Christofides¹,

Leen²,

Averkiou³

2016

IEEE Trans. Med. Imaging

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“…In this work, the temporalmean of the envelope signal, the 2 nd and 4 th order central moments of the IQ signal (according to (12)) and the 4 th -order cumulants of the envelope were calculated ( 4 = 4 − 3 2 2 for the same , τ [24]) for a single frame time-lag ( = 1). The spatial map of the calculated moments and cumulants produced high resolution images of the underlying vasculature.…”

Section: Calculation Of High-order Statisticsmentioning

confidence: 99%

“…Since they are similar in size to red blood cells they are purely intravascular and flow throughout the vascular system. CEUS can be used for imaging of perfusion at the capillary level [1], [2] and for estimating blood velocity in small vessels This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 646804-ERC-COG-BNYQ.…”

Section: Introductionmentioning

confidence: 99%

Fast Vascular Ultrasound Imaging With Enhanced Spatial Resolution and Background Rejection

Bar‐Zion

Tremblay-Darveau

Solomon

et al. 2017

IEEE Trans. Med. Imaging

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109

101

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Abstract-Ultrasound super-localization microscopy techniques presented in the last few years enable non-invasive imaging of vascular structures at the capillary level by tracking the flow of ultrasound contrast agents (gas microbubbles). However, these techniques are currently limited by low temporal resolution and long acquisition times. Super-resolution optical fluctuation imaging (SOFI) is a fluorescence microscopy technique enabling sub-diffraction limit imaging with high temporal resolution by calculating high order statistics of the fluctuating optical signal. The aim of this work is to achieve fast acoustic imaging with enhanced resolution by applying the tools used in SOFI to contrast-enhance ultrasound (CEUS) plane-wave scans. The proposed method was tested using numerical simulations and evaluated using two in-vivo rabbit models: scans of healthy kidneys and VX-2 tumor xenografts. Improved spatial resolution was observed with a reduction of up to 50% in the full width half max of the point spread function. In addition, substantial reduction in the background level was achieved compared to standard mean amplitude persistence images, revealing small vascular structures within tumors. The scan duration of the proposed method is less than a second while current superlocalization techniques require acquisition duration of several minutes. As a result, the proposed technique may be used to obtain scans with enhanced spatial resolution and high temporal resolution, facilitating flow-dynamics monitoring. Our method can also be applied during a breath-hold, reducing the sensitivity to motion artifacts.

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Dynamic contrast enhanced ultrasound for therapy monitoring

Cited by 65 publications

References 48 publications

Quantitative [18F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer

Quantitative [18F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer

Evaluation of the Accuracy of Liver Lesion DCEUS Quantification With Respiratory Gating

Fast Vascular Ultrasound Imaging With Enhanced Spatial Resolution and Background Rejection

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