Dynamic crosslinked polymeric nano-prodrugs for highly selective synergistic chemotherapy

Wang, Shi; Song, Yining; Ma, Jingge; Chen, Xinyang; Guan, Yuanhui; Hui, Pei; Yan, Guoqing; Tang, Rupei

doi:10.1016/j.ajps.2022.09.004

Asian Journal of Pharmaceutical Sciences

2022

DOI: 10.1016/j.ajps.2022.09.004

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Dynamic crosslinked polymeric nano-prodrugs for highly selective synergistic chemotherapy

Shi Wang

Yining Song

Jingge Ma

et al.

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Cited by 3 publications

References 38 publications

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Cluster Missile‐Inspired Dynamic Nanocomposite Hydrogel Precisely Mediates Robust Locoregional Tumor Theranostics

Ma,

Gong,

et al. 2024

Adv Funct Materials

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Locoregional injectable tumoral theranostic nanocomposite hydrogels have shown great potential for clinical transformation, owing to their integration of the advantageous features of both systems, whilst simultaneously minimizing their drawbacks. However, how the nanomedicines efficiently escape from hydrogel and circumvent the intrinsically conflicting attributes between tumor penetration and accumulation directly determines the theranostic efficiency. Herein, a cluster missile‐inspired dynamic nanocomposite hydrogel synthesized via Schiff base reaction between crosslinked synergistic size‐changeable nano‐prodrugs (NPs) and glutaraldehyde (GA) is successfully developed. The hydrogel, analogous to a cluster missile, can efficiently release NPs with an initial size of 25.3 nm for deep tumor distribution and cellular internalization by responding to the tumoral extracellular pH, while precisely directing their exceptionally high cellular accumulation and highly selective drug release in response to the tumoral intracellular pH/glutathione (GSH), thereby achieving robust locoregional chemotherapy. Furthermore, platinum heavy metals within NPs confer upon the hydrogel an ability to spatiotemporally monitor dynamic changes in both itself and tumor tissues without necessitating additional conventional imaging agents. Thus, such a cluster missile‐inspired dynamic nanocomposite hydrogel paves the way toward clinical use for precise locoregional tumor theranostics.

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Cluster Missile‐Inspired Dynamic Nanocomposite Hydrogel Precisely Mediates Robust Locoregional Tumor Theranostics

Ma,

Gong,

et al. 2024

Adv Funct Materials

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Selective distribution of silica grafted with crosslinked poly(methyl methacrylate) in poly(methyl methacrylate)/poly (styrene-co-acrylonitrile) blend

Zhong

Zhang

et al. 2023

Polymer

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Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

Jin

Zhou

et al. 2023

Medical Review

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The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.

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Dynamic crosslinked polymeric nano-prodrugs for highly selective synergistic chemotherapy

Cited by 3 publications

References 38 publications

Cluster Missile‐Inspired Dynamic Nanocomposite Hydrogel Precisely Mediates Robust Locoregional Tumor Theranostics

Cluster Missile‐Inspired Dynamic Nanocomposite Hydrogel Precisely Mediates Robust Locoregional Tumor Theranostics

Selective distribution of silica grafted with crosslinked poly(methyl methacrylate) in poly(methyl methacrylate)/poly (styrene-co-acrylonitrile) blend

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

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