Dynamic CT for Detecting Small Hepatocellular Carcinoma: Usefulness of Delayed Phase Imaging

Monzawa, Shuichi; Ichikawa, Tomoaki; Nakajima, Hiroto; Kitanaka, Yuki; Omata, K; Araki, Tsutomu

doi:10.2214/ajr.05.0512

Cited by 110 publications

(56 citation statements)

References 29 publications

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“…This "washout" may be more conspicuous in the delayed compared with the portal venous phase, and in some lesions, "washout" may be depicted only in the delayed phase (53,54). The mechanisms underlying washout appearance in HCC are not fully understood.…”

Section: Diagnosis and Staging Of Hcc With Extracellular Agentsmentioning

confidence: 99%

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

Choi¹,

Lee²,

Sirlin³

2014

Radiology

465

385

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Computed tomography (CT) and magnetic resonance (MR) imaging play critical roles in the diagnosis and staging of hepatocellular carcinoma (HCC). The second article of this two-part review discusses basic concepts of diagnosis and staging, reviews the diagnostic performance of CT and MR imaging with extracellular contrast agents and of MR imaging with hepatobiliary contrast agents, and examines in depth the major and ancillary imaging features used in the diagnosis and characterization of HCC.q RSNA, 2014

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Section: Diagnosis and Staging Of Hcc With Extracellular Agentsmentioning

confidence: 99%

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

Choi¹,

Lee²,

Sirlin³

2014

Radiology

465

385

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“…In fact, advances in cross-sectional imaging have led to a drastic limitation in the requirement for biopsy of focal lesions in the cirrhotic liver [6,7] . In this setting, good quality contrast enhanced computed tomography (CT) and magnetic resonance imaging (MRI) are generally highly accurate for the diagnosis of HCC [8,9] . However, biopsy remains very important in patients with a liver nodule without typical radiological features (hypervascularization in arterial phase followed by venous wash-out in portal/venous phase) [5,10] , or when α-fetoprotein levels are not diagnostic of HCC (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Needle track seeding following percutaneous procedures for hepatocellular carcinoma

Cabibbo

Craxı̀²

2009

WJH

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Neoplastic seeding may arise after diagnostic or therapeutic percutaneous procedures for hepatocellular carcinoma. The true incidence of seeding with hepatocellular carcinoma is difficult to assess precisely, but a significant risk of seeding exists and is greater when performing diagnostic biopsy as compared to therapeutic percutaneous procedures [radiofrequency ablation, radiofrequency ablation (RFA); percutaneous ethanol injection, Percutaneous ethanol injection (PEI)]. Whenever liver transplantation is feasible, diagnostic needle biopsies should be avoided, but RFA and PEI are often needed as "bridge" treatments. The role of adjuvant treatments in reducing the incidence of seeding following RFA or PEI requires further evaluation.

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“…In comparison with previous study; the small size HCC lesions < 2cm 2 mostly appear as hyper-dense in the arterial and venous phase because the blood supply was so good enough with minimum necrotic tissues. In such realm Monzawa et al [24], found that some HCCs, especially small or well-differentiated lesions, may not be hyper-enhancing on arterial phase images, and only 58% of HCCs < 2 cm were hyper-vascular on the arterial phase. Conversely, a minority of hypervascular HCCs may not exhibit washout on portal venous or delayed phase image; as has been stated by Lee et al [25].…”

Section: Resultsmentioning

confidence: 99%

Characterization of Hepatocellular Carcinoma Using CT Intensity and K-means

2016

IJSR

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The aim of this study was to characterize the hepatocellular carcinoma HCC CT intensity relative to normal liver tissue and other abdominal organs kidney, pancreas and stomach. The method used was the texture analysis which is depends on the collection of CT Number in Hounsfield Unit as excerpted from the k-means technique and the CT system used was tri-phases multidetector computerized tomography MDCT. The analyzed data showed that: the detected mean size of HCC lesions was 11.2±5.3 cm 2 . And the mean intensity in HU of the selected abdominal classes i.e. HCC, liver, kidney, spleen and stomach were (111, 146, 137), (128, 172.1, 158), (172, 221, 207.6), (142, 188, 174), (151, 196, 182.7) during plain, arterial and venous phases respectively. While the ultimate golden scored was the intensity% of HCC relative to normal liver, kidney, spleen and stomach through the different imaging phases (plain, arterial and venous), were: 1%, 26%, 83%, 42% and 80% respectively.

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Dynamic CT for Detecting Small Hepatocellular Carcinoma: Usefulness of Delayed Phase Imaging

Abstract: Delayed phase imaging is useful for detecting small HCCs and should be included in dynamic CT examinations of patients with liver cirrhosis.

Cited by 110 publications

References 29 publications

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

Needle track seeding following percutaneous procedures for hepatocellular carcinoma

Characterization of Hepatocellular Carcinoma Using CT Intensity and K-means

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