Dynamic CT myocardial perfusion measurements of resting and hyperaemic blood flow in low-risk subjects with 128-slice dual-source CT

Ho, Kheng-Thye; Ong, Hean‐Yee; Tan, Grace Fangmin; Yong, Quek Wei

doi:10.1093/ehjci/jeu200

Cited by 41 publications

(31 citation statements)

References 24 publications

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“…In order to enable accurate interpretation of quantitative MBF values, a large database on normal values including physiological regional heterogeneity and establishment of the prognostic implication of MBF value are arguably necessary. Only limited data are available on normal MBF values at this point [58,59] (Table 3).…”

Section: Diagnostic Performance Of Dynamic Ctpmentioning

confidence: 99%

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Dynamic CT Perfusion Imaging: State of the Art

Kitagawa

Goto

Nakamura

et al. 2018

Cardiovasc Imaging Asia

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Recent advances in computed tomography (CT) technology have enabled stress dynamic CT perfusion (CTP) imaging of the entire myocardium to be performed with high temporal resolution and reasonable radiation dose. The most important advantage of dynamic CTP is the feasibility of complete quantification of myocardial perfusion in mL/min/g. Although high diagnostic values have been reported for the detection of myocardial ischemia, standardization of acquisition method, mathematical modeling and interpretation, as well as further evaluation of its accuracy, clinical role, and cost effectiveness are required before its routine clinical implementation. The current review focuses on the state-of-the-art of dynamic CTP and outlines its current status and future directions as a new technology for the physiologic assessment of coronary artery disease.

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Section: Diagnostic Performance Of Dynamic Ctpmentioning

confidence: 99%

“…Rest dynamic CTP has been performed in few limited research environments [23,58,59,63]. This is simply because CCTA has higher priority than quantitative perfusion information at resting state.…”

Section: Rest Dynamic Ctpmentioning

confidence: 99%

Dynamic CT Perfusion Imaging: State of the Art

Kitagawa

Goto

Nakamura

et al. 2018

Cardiovasc Imaging Asia

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“…Furthermore, considerable regional heterogeneity of the myocardial perfusion across coronary territories has been demonstrated in healthy and low-risk subjects (75,76). The natural intra-individual heterogeneity of regional MBF and large inter-individual range of MBF values have been previously documented in the PET and MRI literature (76), and necessitate the implementation of large databases on normal perfusion values such as for nuclear imaging to enable accurate interpretation of quantitative CTP data (27).…”

Section: Ctp Imagingmentioning

confidence: 99%

“…The natural intra-individual heterogeneity of regional MBF and large inter-individual range of MBF values have been previously documented in the PET and MRI literature (76), and necessitate the implementation of large databases on normal perfusion values such as for nuclear imaging to enable accurate interpretation of quantitative CTP data (27).…”

Section: Ctp Imagingmentioning

confidence: 99%

“…Most of the existing evidences on global myocardial flow have utilized PET flow imaging, with values of rest and hyperemic flow ranging from 0.65 to 1.10 and 1.86 to 4.35 mL/g/min, and a CFR value of 3.16-4.99 (76). However, the rest and hyperemic flow in the CTP studies is within the documented range of that in PET studies, though the CFR is systematically lower due to an underestimation of MBF, with values in the range of 1.5-2.0 (76,93). Probably this difference may be related to intrinsic differences in the techniques and contrast or tracer uptake kinetics, to the two-compartment model analysis and limited temporal sampling of dynamic CTP.…”

Section: Advantages Limitations and Future Perspectivesmentioning

confidence: 99%

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Myocardial blood flow quantification for evaluation of coronary artery disease by computed tomography

Cademartiri

Seitun

Clemente

et al. 2017

Cardiovasc. Diagn. Ther.

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During the last decade coronary computed tomography angiography (CTA) has become the preeminent noninvasive imaging modality to detect coronary artery disease (CAD) with high accuracy.However, CTA has a limited value in assessing the hemodynamic significance of a given stenosis due to a modest specificity and positive predictive value. In recent years, different CT techniques for detecting myocardial ischemia have emerged, such as CT-derived fractional flow reserve (FFR-CT), transluminal attenuation gradient (TAG), and myocardial CT perfusion (CTP) imaging. Myocardial CTP imaging can be performed with a single static scan during first pass of the contrast agent, with monoenergetic or dualenergy acquisition, or as a dynamic, time-resolved scan during stress by using coronary vasodilator agents (adenosine, dipyridamole, or regadenoson). A number of CTP techniques are available, which can assess myocardial perfusion in both a qualitative, semi-quantitative or quantitative manner. Once used primarily as research tools, these modalities are increasingly being used in routine clinical practice. All these techniques offer the substantial advantage of combining anatomical and functional evaluation of flow-limiting coronary stenosis in the same examination that would be beneficial for clinical decision-making. This review focuses on the state-of the-art and future trends of these evolving imaging modalities in the field of cardiology for the physiologic assessments of CAD.

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CT Myocardial Perfusion Imaging

2019

Computed Tomography

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Dynamic CT myocardial perfusion measurements of resting and hyperaemic blood flow in low-risk subjects with 128-slice dual-source CT

Abstract: Baseline, hyperaemic MBF and CFR values in a low-risk cohort can be evaluated with dynamic myocardial perfusion imaging using 80 kV.

Cited by 41 publications

References 24 publications

Dynamic CT Perfusion Imaging: State of the Art

Dynamic CT Perfusion Imaging: State of the Art

Myocardial blood flow quantification for evaluation of coronary artery disease by computed tomography

CT Myocardial Perfusion Imaging

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