Dynamic CT vs 0.5 T MR Imaging in the Detection of Surgically Proven Hepatic Metastases

Zeman, Robert K.; Dritschilo, Anatoly; Silverman, Paul M.; Clark, Letitia R.; Garra, Brian S.; Thomas, David S.; Ahlgren, James D.; Smith, Frederick P.; Korec, Stefan M.; Nauta, Russell J.; Dillon, John S.

doi:10.1097/00004728-198907000-00015

Cited by 12 publications

(4 citation statements)

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“…The detectability of liver metastases is especially important in patients with colorectal tumors (I, [16][17][18]. The number and location of these lesions are crucial factors for therapeutic decisions (19,20).…”

Section: Discussionmentioning

confidence: 99%

“…Several comparative studies have raised controversial viewpoints about the first-choice examination among computed tomography, computed tomography during arterial portography, ultrasonography, and MR for accurate detection of focal liver lesions. The detectability of liver metastases is especially important in patients with colorectal tumors (I, [16][17][18]. The number and location of these lesions are crucial factors for therapeutic decisions (19,20).…”

Section: Discussionmentioning

confidence: 99%

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Detection and characterization of primary liver cancer in rats by MS‐264‐enhanced MRI

Petré

Ni²,

Marchal

et al. 1996

Magnetic Resonance in Med

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A new MR contrast agent, MS-264 (Gd(1RS)-1-(p-butylbenzyl)-DTPA), was developed to achieve hepatobiliary specificity and its potential evaluated for detecting and characterizing liver tumors in rats with chemically induced hepatocellular carcinoma (HCC). In seven rats with 66 HCC lesions, enhancements of different abdominal organs and tumors were compared on T1-weighted images after intravenous administration of Gd-DTPA (0.3 mmol/kg) and MS-264 (0.05 mmol/kg). MR images were correlated with postmortem microangiographic and histological findings. An overall enhancement of different organs, which normalized within 24 h, was observed after Gd-DTPA and MS-264 injection. MS-264 caused a higher relative enhancement (RE) in liver (60%), compared with that of Gd-DTPA (40%), which resulted in a prompt negative contrast enhancement in 59 of 66 HCCs. All were moderately to poorly differentiated (Grades II-IV) tumors. Six of these 59 negative contrast-enhancing lesions showed a positively enhanced peritumoral rim, which corresponded histologically to malignant infiltration (n = 2) or compression (n = 4). On the other hand, six well differentiated HCCs showed prolonged positive enhancement. However, one well differentiated HCC was not positively enhanced by MS-264, probably due to poor access of the agent to the lesion. In comparison to that of the precontrast images, enhancement with Gd-DTPA and MS-264 increased the number of detected lesions by 22 and 42%, respectively. In this animal study, MS-264 proved to be useful in detection and characterization of primary liver cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection and characterization of primary liver cancer in rats by MS‐264‐enhanced MRI

Petré

Ni²,

Marchal

et al. 1996

Magnetic Resonance in Med

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show abstract

“…MRI is known to provide excellent contrast resolution within soft tissues. Some studies have shown that MRI is superior to contrast-enhanced CT for detection (4)(5)(6)(7)(8)(9) and characterization (5,7,9) of focal hepatic lesions. However, these studies did not utilize spiral CT.…”

mentioning

confidence: 99%

“…Early studies performed at relatively low field strengths (less than 0.5 T) suggested that T1-weighted sequences were the most effective for detecting focal lesions (4,7,10). However, more recent studies performed at higher field strength have shown that T2-weighted sequences are more sensitive than T1-weighted sequences for lesion detection (10)(11)(12)(13) and characterization (14).…”

mentioning

confidence: 99%