Dynamic CTA in Native Kidneys Using a Multiphase CT Protocol—Potential of Significant Reduction of Contrast Medium

Braunagel, Margarita; Ortner, Florian; Schönermarck, Ulf; Habicht, Antje; Schindler, Andreas; Stangl, Manfred; Strobl, Frederik F.; Reiser, Maximilian; Clevert, D.‐A.; Trumm, Christoph; Helck, Andreas

doi:10.1016/j.acra.2017.11.012

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Computed tomography angiography (CTA), magnetic resonance angiography (MRA), X-ray arteriography, Doppler blood vessel ultrasound, and other related technologies provide a pivotal imaging basis for the analysis of blood vessel structure, and consequently play a crucial diagnostic role in diseases involving renal vessels, coronary vessels, liver vessels, and so on [6][7][8]. However, there is still a considerable gap between the collected imaging data and the actual lesions.…”

Section: Introductionmentioning

confidence: 99%

Establishment of Standard Human Blood Vessel Model Based on Image Registration and Fitting Technology

Luo

Wang

et al. 2022

J. Med. Biol. Eng.

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Purpose The blood vessel gives key information for pathological changes in a variety of diseases. In view of the crucial role of blood vessel structure, the present study aims to establish a digital human blood vessel standard model for diagnosing blood vessel-related diseases. Methods The present study recruited eight healthy volunteers, and reconstructed their bilateral upper extremity arteries according to CTA. The reconstructed vessels were segmented, registered, and merged into a bunch. After being cut by continuous cut planes, the dispersion of the blood vessel bunches on each cut plane were calculated. Results The results demonstrated that the middle segment of the brachial artery, the proximal segment of the ulnar artery, and the middle and distal segments of the radial artery had a low degree of dispersion. A standard blood vessel model was finally established by the integral method using the low-dispersion segments above. The accuracy of the standard blood vessel model was also verified by an actual contralateral vessel, which revealed that the deviation between the model and the actual normal contralateral brachial artery was relatively small. Conclusion The structure of the model was highly accordant with the real ones, which can be of great help in evaluating the blood vessel changes in blood vessel-related diseases, bone and soft-tissue tumors, and creating accurate surgical plans.

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Section: Introductionmentioning

confidence: 99%

Establishment of Standard Human Blood Vessel Model Based on Image Registration and Fitting Technology

Luo

Wang

et al. 2022

J. Med. Biol. Eng.

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“…Several researchers are pioneering miniaturized, novel methods as point-of-care alternatives to flow cytometry, including fluorescent microfluidics for nucleic acid and protein quantification [19][20][21] , droplet-based microfluidics for secreted biomarker analysis 17,22,23 , planar microarrays with micro-engraving techniques for temporal cell behavior evaluation [24][25][26][27] , and barcoded microchip devices for membrane and cytosolic protein detection [28][29][30] . Such proceedings can be directed for treating complicated and changing diseases requiring multiple biomarker determinations like sepsis 5,7,15,31,32 , HIV/AIDS 9,[33][34][35] , acute kidney injury [36][37][38] , urinary tract infections 12,22 , and malignant tumors 26,30,[39][40][41] . While these technologies may provide adequate capabilities in future developments, many are still lacking in adaptive biomarker targeting, low-cost manufacturing, or reducing blood sample volumes required for testing 7,17,18,42 .…”

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confidence: 99%

Design of a Multiplexed Analyte Biosensor using Digital Barcoded Particles and Impedance Spectroscopy

Prakash

Ashley

Doyle

et al. 2020

Sci Rep

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Multiplexing allows quantifying multiple analytes in a single step, providing advantages over individual testing through shorter processing time, lower sample volume, and reduced cost per test. Currently, flow cytometry is the gold standard for biomedical multiplexing, but requires technical training, extensive data processing, and expensive operational and capital costs. To solve this challenge, we designed digital barcoded particles and a microfluidic architecture for multiplexed analyte quantification. In this work, we simulate and model non-fluorescence-based microfluidic impedance detection with a single excitation and detection scheme using barcoded polymer microparticles. Our barcoded particles can be designed with specific coding regions and generate numerous distinct patterns enabling digital barcoding. We found that signals based on adhered microsphere position and relative orientation were evaluated and separated based on their associated electrical signatures and had a 7 µm microsphere limit of detection. Our proposed microfluidic system can enumerate micronsized spheres in a single assay using barcoded particles of various configurations. As representation of blood cells, the microsphere concentrations may provide useful information on disease onset and progression. Such sensors may be used for diagnostic and management of common critical care diseases like sepsis, acute kidney injury, urinary tract infections, and HIV/AIDS. Whole blood samples provide imperative data useful for healthy monitoring and understanding disease progression for individuals in critical care settings. Each cell type within the blood has unique properties and methods of isolation, including their relative concentration. Currently, as disease onset occurs, a Complete Blood Cell count (CBC) is often the first step for evaluating a patient's status 1. However, the CBC denies the whole story, as different cellular behaviors, organelle or membrane properties, and mechanical responses by the cells are significantly better indicators for accurate disease determination 2,3. More specialized, multiplexed techniques targeting these blood cell biomarkers may be the key for robust and expedient diagnosis. Most diagnostic equipment requires large blood volumes to measure each targeted analyte separately. In these cases, properties of the blood biomarkers may change and will not satisfy test requirements, burdening both patients of compromised function and healthcare providers conducting the blood extractions 4. While gathering information on more analytes provides more accurate diagnostics, usually experiment complexity and data analysis increases alongside it. As a solution. a multiplexing quantification approach for proteins, nucleic acid sequences, or cytokines overcomes such issues by detecting each biomarker with the same source and sample volume. These abilities enable multiplexing to obtain high density information in minimal time along with low sample volume and less cost 5. To increase multiplexing solutions for biomedical diagno...

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Dynamic CTA in Native Kidneys Using a Multiphase CT Protocol—Potential of Significant Reduction of Contrast Medium

Cited by 2 publications

References 37 publications

Establishment of Standard Human Blood Vessel Model Based on Image Registration and Fitting Technology

Establishment of Standard Human Blood Vessel Model Based on Image Registration and Fitting Technology

Design of a Multiplexed Analyte Biosensor using Digital Barcoded Particles and Impedance Spectroscopy

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