As part of the joint research project Carbon2Chem®, mathematical models are used to simulate operating scenarios of cross‐industry networks, in particular chemical plants in industrial environments with high CO2 emissions. In this context, a cloud‐based distributed co‐simulation is used to enable the parallelized simulation of a large number of different variants. This enables optimal design of the plant networks and the efficient determination of optimal operating conditions. The architecture of this approach is described, and its performance is examined and evaluated.