Dynamic diffuse optical tomography imaging of peripheral arterial disease

Khalil, Michael A.; Kim, Hyun Koo; Kim, In Kyong; Flexman, Molly; Dayal, Rajeev; Shrikhande, Gautam; Hielscher, Andreas H.

doi:10.1364/boe.3.002288

Cited by 51 publications

(36 citation statements)

References 18 publications

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“…Near-infrared spectroscopy (NIRS) is a rapidly evolving non-invasive technique applied to study oxygenation-related processes in biological tissue [1][2][3] and to facilitate the diagnosis of diseases associated with abnormal oxygen supply to tissue, such as stroke [4], cancer [5], peripheral arterial disease [6], or traumatic brain injury [7]. However, despite the recent impressive growth of NIRS applications -there are 42 NIRS clinical studies currently underway around the world [8] -there are still some drawbacks compared to other imaging modalities (e.g.…”

Section: Introductionmentioning

confidence: 99%

Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Mazurenka¹,

Sieno²,

Boso³

et al. 2013

Biomed. Opt. Express

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Abstract:We report on the design and first in vivo tests of a novel noncontact scanning imaging system for time-domain near-infrared spectroscopy. Our system is based on a null source-detector separation approach and utilizes polarization-selective detection and a fast-gated single-photon avalanche diode to record late photons only. The in-vivo tests included the recording of hemodynamics during arm occlusion and two brain activation tasks. Localized and non-localized changes in oxy-and deoxyhemoglobin concentration were detected for motor and cognitive tasks, respectively. The tests demonstrate the feasibility of non-contact imaging of absorption changes in deeper tissues.

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Section: Introductionmentioning

confidence: 99%

Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Mazurenka¹,

Sieno²,

Boso³

et al. 2013

Biomed. Opt. Express

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“…Wang 53 used a binarized segmentation technique to select the regions with the dominant response, while in another study by Cuccia et al, 54 regions with large vessels were avoided to focus on regions containing only microvasculature. Recently, Khalil et al 55 employed correlation analysis to define regions of temporal consistency that correlate significantly with the averaged HbT. Their results showed some differences in the evolution of HbT between a healthy volunteer and a patient with PAD, which were not evident from the average signals alone.…”

Section: Regions Of Hemodynamic Consistencementioning

confidence: 99%

Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography

et al. 2016

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Coca, "Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography," J. Biomed. Opt. 21(6), 066012 (2016), doi: 10.1117/1.JBO.21.6.066012. Abstract. The application of near-infrared spectroscopy (NIRS) to assess microvascular function has shown promising results. An important limitation when using a single source-detector pair, however, is the lack of depth sensitivity. Diffuse optical tomography (DOT) overcomes this limitation using an array of sources and detectors that allow the reconstruction of volumetric hemodynamic changes. This study compares the key parameters of postocclusive reactive hyperemia measured in the forearm using standard NIRS and DOT. We show that while the mean parameter values are similar for the two techniques, DOT achieves much better reproducibility, as measured by the intraclass correlation coefficient (ICC). We show that DOT achieves high reproducibility for muscle oxygen consumption (ICC: 0.99), time to maximal HbO 2 (ICC: 0.94), maximal HbO 2 (ICC: 0.99), and time to maximal HbT (ICC: 0.99). Absolute reproducibility as measured by the standard error of measurement is consistently smaller and close to zero (ideal value) across all parameters measured by DOT compared to NIRS. We conclude that DOT provides a more robust characterization of the reactive hyperemic response and show how the availability of volumetric hemodynamic changes allows the identification of areas of temporal consistency, which could help characterize more precisely the microvasculature. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…[4][5][6][7][8] In the wavelength range from 600 nm to 1100 nm, tissues behave as weakly absorbing but highly scattering media and light can deeply penetrate: this enables to estimate the concentration of dominant absorbers in the biological tissue (like hemoglobin, water, and lipids). In recent years, various attempts have been worked out to use nearinfrared spectroscopy (NIRS) in different clinical applications to obtain, for example, information about the oxygenation of blood in tissues [9][10][11][12][13] or for other diagnostics purposes. [4][5][6][7][8] In most cases, optical fibers are used to inject light into tissues and a) Author to whom correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Characterization of a time-resolved non-contact scanning diffuse optical imaging system exploiting fast-gated single-photon avalanche diode detection

Sieno

Wabnitz

Pifferi

et al. 2016

Review of Scientific Instruments

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We present a system for non-contact time-resolved diffuse reflectance imaging, based on small source-detector distance and high dynamic range measurements utilizing a fast-gated single-photon avalanche diode. The system is suitable for imaging of diffusive media without any contact with the sample and with a spatial resolution of about 1 cm at 1 cm depth. In order to objectively assess its performances, we adopted two standardized protocols developed for time-domain brain imagers. The related tests included the recording of the instrument response function of the setup and the responsivity of its detection system. Moreover, by using liquid turbid phantoms with absorbing inclusions, depth-dependent contrast and contrast-to-noise ratio as well as lateral spatial resolution were measured. To illustrate the potentialities of the novel approach, the characteristics of the non-contact system are discussed and compared to those of a fiber-based brain imager.

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Dynamic diffuse optical tomography imaging of peripheral arterial disease

Cited by 51 publications

References 18 publications

Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Non-contact in vivo diffuse optical imaging using a time-gated scanning system

Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography

Characterization of a time-resolved non-contact scanning diffuse optical imaging system exploiting fast-gated single-photon avalanche diode detection

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