We are living in a world that is wired differently where almost everything can be made ubiquitously with high degree of connectivity. Such ecosystem of ubiquitous connectivity is a critical piece for the advancements of key industries like manufacturing and healthcare. Both of these industries are transitioning their delivery system from volume based to value based and are looking for new ways to maintain continuity, cut costs, improve quality and increase the levels of interoperability. Accomplishing these goals will help to create a seamless workflow and build a foundation to advance value-based industry. However, manufacturing and healthcare organizations today are balancing the complexities of the using innovative digital transformation technologies with the fusion of working with a multi-disciplinary working teams, designers, developers and customers to achieve enterprise resilience aligned to fiscal and fiduciary responsibility, customer commitments and values, regulatory and compliance requirements and stakeholders' expectations. To integrate such diverse range of perspectives and turn those into meaningful insights requires the planning and enforcement of "Pragmatic Interoperability". This paper describes the authors' vision in developing a flexible workflow infrastructure for enforcing the pragmatic interoperability in industries like manufacturing and healthcare. This vision is based on business continuity planning, web services interoperability, Node-Red, Neo4j and IFTTT workflow technologies.