Dynamic distribution and driving mechanisms of antibiotic resistance genes in a human-intensive watershed

Yang, Jun; Xiang, Jinyi; Xie, Yong; Yu, Kaifeng; Gin, Karina Yew-Hoong; Zhang, Bo; He, Yiliang

doi:10.1016/j.watres.2022.118841

Cited by 38 publications

(3 citation statements)

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“…As shown in the results, cultivation land was the dominant land use (followed by either low/medium-density residential land or Class A/B industrial land) in seven rivers, in which four located in NW (TG, CQ, YC, and SD) and three in the SW (WX, YJP, and DQ) region of the Taihu Lake. Yang et al (2022) studied the distribution and abundance of ARGs in human-intensive watershed (including city, river, and lake systems) and found high abundance of ARGs in surface water and sediments with dominance of ARGs conferring resistance to aminoglycoside, beta-lactam and multidrug resistance genes. High diversity of ARGs in spring and summer and high abundance of ARGs in winter were observed and their study concluded that wastewater and human/animal feces contributed to high abundance of ARGs ( Yang et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“… Yang et al (2022) studied the distribution and abundance of ARGs in human-intensive watershed (including city, river, and lake systems) and found high abundance of ARGs in surface water and sediments with dominance of ARGs conferring resistance to aminoglycoside, beta-lactam and multidrug resistance genes. High diversity of ARGs in spring and summer and high abundance of ARGs in winter were observed and their study concluded that wastewater and human/animal feces contributed to high abundance of ARGs ( Yang et al, 2022 ). The effect of agriculture land-use change on the number and abundance of ARGs in Taihu Lake watershed was studied by Zhang M.-S. et al (2021) and the results showed that more diverse and higher abundance of ARGs were observed in orchard runoffs as compared to the conventional cropland runoffs particularly when the application of organic manure was higher.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the ARB and ARGs are eventually transmitted from environment to human and animals and vice versa. Various factors including the water temperature, flow dynamics and the concentrations of nutrients, heavy metals, antibiotics, and the land use were reported to contribute to the diversity and abundance of ARGs in water environment ( Walsh et al, 2011 ; Yang Y. et al, 2017 ; Ohore et al, 2019 ; Zhang M.-S. et al, 2021 ; Yang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Diversity and abundance of antibiotic resistance genes and their relationship with nutrients and land use of the inflow rivers of Taihu Lake

Fernanda

Liu²,

Yuan³

et al. 2022

Front. Microbiol.

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Taihu Lake is the third largest freshwater lake in China and an important source for drinking water, flood protection, aquaculture, agriculture, and other activities. This lake is connected to many principal and small rivers with inflow from west and outflow on the eastern side of the lake and these inflow rivers are believed to significantly contribute to the water pollution of the lake. This study was aimed at assessing the diversity and abundance of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs), and their relationship with water quality parameters and land use patterns. Water samples were collected from 10 major inflow rivers and the source water protection area of the Taihu Lake in spring and summer 2019. High-throughput profiling was used to detect and quantify 384 ARGs and MGEs and in addition, 11 water quality parameters were analyzed. The results showed that the number of ARGs/MGEs detected in each inflow river ranged from 105 to 185 in spring and 107 to 180 in summer. The aminoglycoside resistance genes were the most dominant types ARGs detected followed by beta-lactam resistance, multidrug resistance, macrolide-lincosamide-streptogramin B (MLSB) resistance genes, which contributed to 65% of the ARGs. The water quality parameters showed significant correlation with absolute abundance of ARGs. Furthermore, significant correlation between ARGs and MGEs were also observed which demonstrates potential gene transfer among organisms through horizontal gene transfer via MGEs. ARGs showed strong positive correlation with cultivated and industrial lands whereas, negative correlation was observed with river, lake, forest, land for green buffer, and land for port and harbor. The overall results indicate that the inflow rivers of Taihu Lake are polluted by various sources including multiple nutrients and high abundance of ARGs, which needs attention for better management of the inflow rivers of this lake.

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Section: Discussionmentioning

confidence: 99%