Dynamic DNA Structures

Zhang, Yingwei; Pan, Victor Y.; Li, Xue; Yang, Xueqin; Li, Haofei; Wang, Pengfei; Ke, Yonggang

doi:10.1002/smll.201900228

Cited by 93 publications

(84 citation statements)

References 68 publications

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“…Such differences in environmental characteristics could serve as another type of target for nanocarriers to aim for. In order to arm pristine DNA nanostructures with stimuli responsive capability, dynamic elements need to be integrated into the designed nanocarrier ( Figure 5A) (Harroun et al, 2018;Zhang Y. et al, 2019). In the following section, we discuss some mechanisms that may be incorporated into DNA nanocarriers to realize environmental responsive cargo delivery.…”

Section: Dna Nanocarriers Responding To Microenvironmentsmentioning

confidence: 99%

“…These unique properties make DNA-based nanomaterials an attractive drug delivery system. After introducing responsive components, DNA nanocarriers can acquire dynamic capabilities in response to a variety of physiological or non-physiological stimuli (Zhang Y. et al, 2019). However, the high complexity of in vivo microenvironments poses great challenges to their proper performance in living organisms (Zhao Z. et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Rationally Designed DNA Nanostructures for Drug Delivery

Xia

Wang

2020

Front. Chem.

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DNA is an excellent biological material that has received growing attention in the field of nanotechnology due to its unique capability for precisely engineering materials via sequence specific interactions. Self-assembled DNA nanostructures of prescribed physicochemical properties have demonstrated potent drug delivery efficiency in vitro and in vivo. By using various conjugation techniques, DNA nanostructures may be precisely integrated with a large diversity of functional moieties, such as targeting ligands, proteins, and inorganic nanoparticles, to enrich their functionalities and to enhance their performance. In this review, we start with introducing strategies on constructing DNA nanostructures. We then summarize the biological barriers ahead of drug delivery using DNA nanostructures, followed by introducing existing rational solutions to overcome these biological barriers. Lastly, we discuss challenges and opportunities for DNA nanostructures toward real applications in clinical settings.

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Section: Dna Nanocarriers Responding To Microenvironmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rationally Designed DNA Nanostructures for Drug Delivery

Xia

Wang

2020

Front. Chem.

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“…TLPs grown on origami templates may thus find their way into hierarchically organized smart hybrid materials (Hu & Niemeyer, ) and elaborate dynamic nano‐ and microstructures such as microrobots soon (Ijäs, Nummelin, Shen, Kostiainen, & Linko, ; Palagi & Fischer, ; J.‐T. Zhang et al, ).…”

Section: Bottom‐up Growth Of Lawns and Starsmentioning

confidence: 99%

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

Wege

Koch

2019

WIREs Nanomed Nanobiotechnol

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The self‐assembly of viral building blocks bears exciting prospects for fabricating new types of bionanoparticles with multivalent protein shells. These enable a spatially controlled immobilization of functionalities at highest surface densities—an increasing demand worldwide for applications from vaccination to tissue engineering, biocatalysis, and sensing. Certain plant viruses hold particular promise because they are sustainably available, biodegradable, nonpathogenic for mammals, and amenable to in vitro self‐organization of virus‐like particles. This offers great opportunities for their redesign into novel “green” carrier systems by spatial and structural synthetic biology approaches, as worked out here for the robust nanotubular tobacco mosaic virus (TMV) as prime example. Natural TMV of 300 x 18 nm is built from more than 2,100 identical coat proteins (CPs) helically arranged around a 6,395 nucleotides ssRNA. In vitro, TMV‐like particles (TLPs) may self‐assemble also from modified CPs and RNAs if the latter contain an Origin of Assembly structure, which initiates a bidirectional encapsidation. By way of tailored RNA, the process can be reprogrammed to yield uncommon shapes such as branched nanoobjects. The nonsymmetric mechanism also proceeds on 3'‐terminally immobilized RNA and can integrate distinct CP types in blends or serially. Other emerging plant virus‐deduced systems include the usually isometric cowpea chlorotic mottle virus (CCMV) with further strikingly altered structures up to “cherrybombs” with protruding nucleic acids. Cartoon strips and pictorial descriptions of major RNA‐based strategies induct the reader into a rare field of nanoconstruction that can give rise to utile soft‐matter architectures for complex tasks. This article is categorized under: Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures

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“…), as shown in Figure b. For additional information regarding dynamic DNA assembly, one can refer to a recent review on this topic . Krishnan and co‐workers designed a I‐motif‐based pH sensor (I‐switch) to map internal pH changes of cellular organelles in living cells (Figure c) .…”

Section: Dna‐guided Assembly Of Molecules Materials and Cellsmentioning

confidence: 99%

DNA‐Guided Assembly of Molecules, Materials, and Cells

Yang

Zhou

Gao

et al. 2019

Advanced Intelligent Systems

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DNA is the genetic blueprint for most known living organisms on Earth, but it is not merely the secret of life. Because of its programmability derived from Watson-Crick base-pairing, DNA exhibits unparalleled versatility in constructing designer molecular structures by self-assembly-a field called DNA nanotechnology. After decades of active pursuit, DNA has demonstrated unprecedented capability in designing highly prescribed and sophisticated artificial nanostructures, which could be either static, with well-controlled physicochemical properties, or dynamic, with the ability to change in response to external stimuli. Researchers have devoted considerable efforts to exploring the utility of DNA nanotechnology in a variety of fields, with the majority related to harvesting their assembling power, since they are highly capable of guiding the assembly of other entities-molecules, materials, living cells, and so on-to fabricate artificial assemblies with emergent properties and functions. Herein, a brief introduction is given to self-assembly methods in DNA nanotechnology, including DNA tiles, modular DNA bricks, and DNA origami. Four sections are then dedicated to covering the utilization of DNA nanotechnology for guided assembly of organic materials, inorganic materials, biological materials, and living cells. Lastly, DNA-enabled molecular intelligent systems that are able to compute and execute algorithms are discussed.

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Dynamic DNA Structures

Cited by 93 publications

References 68 publications

Rationally Designed DNA Nanostructures for Drug Delivery

Rationally Designed DNA Nanostructures for Drug Delivery

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

DNA‐Guided Assembly of Molecules, Materials, and Cells

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