Dynamic echo-planar imaging of the breast: experience in diagnosing breast carcinoma and correlation with tumor angiogenesis.

Hulka, Carol A.; Edmister, Whitney B.; Smith, Benjamin L.; Tan, Li Tee; Sgroi, Dennis; Campbell, T; Kopans, Daniel B.; Weisskoff, Robert M.

doi:10.1148/radiology.205.3.9393545

Cited by 154 publications

(90 citation statements)

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“…Previously, the presence of increased blood flow in breast tumors has also been demonstrated using positron emission tomography (13), temporally-resolved contrast-enhanced MRI (14)(15)(16)(17), and color Doppler ultrasonography (18). Furthermore, an ipsilateral association between cancer and increased breast vascularity has been demonstrated using conventional MRI (19,20).…”

Section: Discussionmentioning

confidence: 98%

3D vascular mapping of breast using contrast enhanced mri: association of unilateral increased vascularity with ipsilateral breast cancer

Örgüç

Başara²,

Coşkun³

et al. 2012

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 98%

3D vascular mapping of breast using contrast enhanced mri: association of unilateral increased vascularity with ipsilateral breast cancer

Örgüç

Başara²,

Coşkun³

et al. 2012

Diagn Interv Radiol

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“…Hulka et al (12) initially published a series of 22 lesions and found an overall positive, but not statistically significant, correlation between extraction-flow product and microvessel density. They further expanded their study to include 71 lesions and found an overall significant correlation between extraction-flow product and microvessel density, but the correlation was not significant in the subgroup of benign or malignant cancers (13). Studying 25 malignant and 23 benign lesions, Stomper et al (15) found a significant association between increased intratumor vessel density (factor VIII) and greater MR enhancement, but not with the washout rate.…”

Section: Discussionmentioning

confidence: 99%

“…We only included malignant cancers in this series. Benign lesions often had lower early enhancements and lower vascular density (12,13). If benign lesions were to be included, the spectrum would be widened and an improved correlation should be expected.…”

Section: Discussionmentioning

confidence: 99%

“…To further understand the pathophysiological basis for dynamic contrast enhancement properties in breast cancer, several investigators evaluated the association between MRI parameters and the angiogenic markers, such as quantitative microvessel density or vascular endothelial growth factor (VEGF) expression measured by immunohistochemistry (IHC) (12)(13)(14)(15)(16). Microvessel density is commonly used as a surrogate for angiogenesis and has been shown to be an independent prognostic factor associated with relapse-free and overall survival of breast cancer patients (17)(18)(19).…”

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confidence: 99%

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Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer

Cheung

Fruehauf

et al. 2003

Magnetic Resonance Imaging

150

115

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Purpose:To investigate the association between parameters obtained from dynamic contrast enhanced MRI (DCE-MRI) of breast cancer using different analysis approaches, as well as their correlation with angiogenesis biomarkers (vascular endothelial growth factor and vessel density).Materials and Methods: DCE-MRI results were obtained from 105 patients with breast cancer (108 lesions). Three analysis methods were applied: 1) whole tumor analysis, 2) regional hot-spot analysis, and 3) intratumor pixel-by-pixel analysis. Early enhancement intensities and fitted pharmacokinetic parameters were studied. Paraffin blocks of 71 surgically resected specimens were analyzed by immunohistochemical staining to measure microvessel counts (with CD31) and vascular endothelial growth factor (VEGF) expression levels.Results: MRI parameters obtained from the three analysis methods showed significant correlations (P Ͻ 0.0001), but a substantial dispersion from the linear regression line was noted (r ϭ 0.72-0.97). The entire region of interest (ROI) vs. pixel population analyses had a significantly higher association compared to the entire ROI vs. hot-spot analyses. Cancer specimens with high VEGF expression had significantly higher CD31 microvessel densities than did specimens with low VEGF levels (P Ͻ 0.005). No significant association was found between MRI parameters obtained from the three analysis strategies and IHC based measurements of angiogenesis. Conclusion:A consistent analysis strategy was important in the DCE-MRI study. In this series, none of these strategies yielded results for MRI based quantitation of tumor vascularity that were associated with IHC based measurements. Therefore, different analyses could not account for the lack of association.

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“…10,11 Some studies have shown the rapid uptake patterns of invasive cancers on DEC-MRI reflect high intratumor angiogenesis. 12,13 It has been reported that DCE-MRI is useful for the differential diagnosis of some tumors, and many investigators have attempted to identify the differences between benign and malignant tumors by analyzing curve patterns such as rapid uptake or gradual increase from the time course of dynamic contrast enhancement. 14, 15 Therefore, we may be able to differentiate unilocular cystic lesions including ameloblastomas by detecting nodular regions on CE-MRI and/or DEC-MRI, or by detecting areas of high intratumor angiogenesis on DEC-MRI.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of dynamic contrast-enhanced MRI for unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2-weighted or STIR MR images

et al. 2011

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Telephone number: +81-86-235-6705 FAX number: +81-86-235-6709 SUMMARY Typical MR images of ameloblastomas on T2-weighted image (WI) or short inversion time inversion-recovery (STIR) show multiple bright high-signal-intensity loci on a high-signal-intensity background. Unilocular cystic-type ameloblastomas show homogeneously bright high signal intensity on T2WI or STIR as a water-like signal intensity. Therefore, it is difficult to distinguish unilocular cystic-type ameloblastoma from other cystic lesions such as keratocystic odontogenic tumors, radicular cysts (residual cysts) and dentigerous cysts only on the basis of MRI signal intensity. In the present study, we evaluated whether contrast-enhanced (CE)-T1WI and dynamic CE-MRI (DCE-MRI) could provide additional information for differential diagnosis in unilocular cystic-type ameloblastoma. Images from 12 cases of suspected unilocular cystic-type ameloblastoma were evaluated in the present study. Of them, 5 had areas suspected of indicating a solid component on T1WI and T2WI (or STIR). Ten had undergone additional CE-T1WI and DCE-MRI. On 5 of 10 cases of CE-T1WI, a tiny enhancement area was detected. On 6 of 10 DCE-images, a time-course enhanced area which was suspected to be a solid component was detected. CE-T1WI was helpful in the diagnosis of ameloblastoma because the tiny enhanced areas were taken to indicate possible solid components. Moreover, the rim-enhancement area on CE-T1WI could be divided into small regions of interest, and some of these showed slightly increased enhancement on DCE-MRI, which was taken to indicate a solid component and/or intramural nodule with focal invasion of ameloblastoma tissue. DCE-MRIs of the 4 remaining cases, which provided no clues to the diagnosis of ameloblastoma in the manner of the above descriptions, showed thicker rim enhancement than odontogenic cysts. Thus, CE-T1WI and DCE-MRI were helpful in the differential diagnosis of unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2WI or STIR.

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Dynamic echo-planar imaging of the breast: experience in diagnosing breast carcinoma and correlation with tumor angiogenesis.

Abstract: The T1 value remains important in more precise quantitative estimation of gadopentetate dimeglumine uptake in breast tumors, which helps improve the specificity of dynamic imaging. Tumor MVD affects the contrast medium enhancement of breast lesions, but other factors contribute.

Cited by 154 publications

References 0 publications

3D vascular mapping of breast using contrast enhanced mri: association of unilateral increased vascularity with ipsilateral breast cancer

3D vascular mapping of breast using contrast enhanced mri: association of unilateral increased vascularity with ipsilateral breast cancer

Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer

Diagnostic value of dynamic contrast-enhanced MRI for unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2-weighted or STIR MR images

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