Dynamic endorectal magnetic resonance imaging for local staging and detection of neurovascular bundle involvement of prostate cancer: correlation with histopathologic results

Ogura, Keiji; Maekawa, Shinya; Okubo, Kazutoshi; Aoki, Yoshitaka; Okada, Takashi; Oda, Kazushige; Watanabe, Yuji; Tsukayama, Chotatsu; Arai, Yoichi

doi:10.1016/s0090-4295(00)01072-4

Cited by 137 publications

(70 citation statements)

References 9 publications

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“…It is impractical to perform an MRI study of the spine, although it is highly sensitive, in all patients with newly diagnosed prostate carcinoma. 18,19 Serial bone scans have been a standard diagnostic component for patients who have undergone radical prostatectomy. The findings on the initial bone scan are important in determining whether increased tracer uptake on serial bone scans is indicative of a malignant lesion or a benign lesion.…”

Section: Discussionmentioning

confidence: 99%

Can initial prostate specific antigen determinations eliminate the need for bone scans in patients with newly diagnosed prostate carcinoma?

Kosuda

Yoshimura

Aizawa³

et al. 2002

Cancer

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Type 1 diabetes is considered to be an autoimmune disease in which T lymphocytes infiltrate the islets of pancreas and destroy the insulin producing beta cell population. Besides antigen specificity, the quality of immune reactivity against islet cell antigen(s) is an important determinant of the beta cell destruction. Much evidence indicates that the function of the gut immune system is central in the pathogenesis, as the regulation of the gut immune system may be aberrant in type 1 diabetes. The role of virus infections in the pathogenesis of type 1 diabetes has been supported by substantial new evidence suggesting that one virus group, enteroviruses, may trigger the beta‐cell damaging process in a considerable proportion of patients. The latest evidence comes from studies indicating the presence of viral genome in diabetic patients and from prospective studies confirming epidemiological risk effect. If this association holds still true in ongoing large‐scale studies, intervention trials should be considered to confirm causality. Of the dietary putative etiological factors, cow's milk proteins have received the main attention. Many studies indicate an association between early exposure to dietary cow's milk proteins and an increased risk of type 1 diabetes. The question will be answered by a large scale, prospective, randomized, international intervention trial. Another dietary factor in need of more studies is the deficiency of vitamin D. Among toxins, N‐nitroso compounds are the main candidates. An interaction of genetic and environmental factors is important in evaluating the possible role of a certain environmental factor in the etiology of type 1 diabetes. © 2002 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Can initial prostate specific antigen determinations eliminate the need for bone scans in patients with newly diagnosed prostate carcinoma?

Kosuda

Yoshimura

Aizawa³

et al. 2002

Cancer

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“…The qualitative analysis of the DCE images [107][108][109] is based on the premise that the blood vessels recruited by the prostate tumors are leaky [110,111]. When the contrast is injected, the cancerous tissues demonstrate early and rapid enhancement followed by a quick washout, which is noticeably different from a slow and steady enhancement observed for normal tissues.…”

Section: Dynamic Contrast-enhanced Imagingmentioning

confidence: 99%

Practical aspects of prostate MRI: hardware and software considerations, protocols, and patient preparation

et al. 2015

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The use of multiparametric MRI scans for the evaluation of men with prostate cancer has increased dramatically and is likely to continue expanding as new developments come to practice. However, it has not yet gained the same level of acceptance of other imaging tests. Partly, this is because of the use of suboptimal protocols, lack of standardization, and inadequate patient preparation. In this manuscript, we describe several practical aspects of prostate MRI that may facilitate the implementation of new prostate imaging programs or the expansion of existing ones.

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“…All of these techniques employed 2D acquisition techniques with relatively thick (>5mm) sections and intersection gaps resulting in a substantial degree of image undersampling of the gland. Prior dynamic contrast enhanced imaging has focused on low spatial resolution and high temporal resolution [75,76]. However, tumor detection rates were still limited: the overall sensitivity, specificity, and accuracy of the detection of cancer in the prostate gland was 59%, 88%, and 72%, respectively [76].…”

Section: Dce Mri and Detection Of Ece Of Prostate Cancermentioning

confidence: 99%

The role of magnetic resonance imaging (MRI) in prostate cancer imaging and staging at 1.5 and 3 Tesla: The Beth Israel Deaconess Medical Center (BIDMC) approach

Bloch

Lenkinski

Rofsky

2008

CBM

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Management decisions for patients with prostate cancer present a dilemma for both patients and their clinicians because prostate cancers demonstrate a wide range in biologic activity, with the majority of cases not leading to a prostate cancer related death. Furthermore, the current treatment options have significant side effects, such as incontinence, rectal injury and impotence. Key elements for guiding appropriate treatment include: distinction of organ-confined disease from extracapsular extension (ECE); and determination of tumor volume and tumor grade, none of which have been satisfactorily accomplished in today's pre-treatment paradigm. Magnetic resonance imaging (MRI) has the capability to assess prostate tissue, both functionally and morphologically. MRI as a staging tool has not shown enough consistency or sufficient accuracy for widespread adoption in clinical practice; yet, recent technical developments in MRI have yielded improved results. At our institution we have combined the use of new endorectal 3 Tesla MRI technology, T2-weighted, and high spatial resolution dynamic-contrast enhanced (DCE) MRI to non-invasively assess the prostate with higher signal-to-noise ratio and spatial resolution than previously achieved. This approach allows assessment of prostate-tissue morphology and kinetics, thus providing a non-invasive tool for tumor detection and staging and, consequently, directing biopsy and treatment specifically to diseased areas for a pre-treatment evaluation that can assist in the rational selection of patients for appropriate prostate cancer therapy.

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Dynamic endorectal magnetic resonance imaging for local staging and detection of neurovascular bundle involvement of prostate cancer: correlation with histopathologic results

Cited by 137 publications

References 9 publications

Can initial prostate specific antigen determinations eliminate the need for bone scans in patients with newly diagnosed prostate carcinoma?

Can initial prostate specific antigen determinations eliminate the need for bone scans in patients with newly diagnosed prostate carcinoma?

Practical aspects of prostate MRI: hardware and software considerations, protocols, and patient preparation

The role of magnetic resonance imaging (MRI) in prostate cancer imaging and staging at 1.5 and 3 Tesla: The Beth Israel Deaconess Medical Center (BIDMC) approach

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