Delta robot is typically mounted on a frame and performs high speed pick and place tasks from top to bottom. Because of its outstanding accelerating capability and higher center of mass, the Delta robot can generate significant frame vibration. Existing trajectory smoothing methods mainly focus on vibration reduction for the robot instead of the frame, and modifying the frame structure increases the manufacturing cost. In this paper, an acceleration profile optimization approach is proposed to reduce the Delta robot-frame vibration. The profile is determined by the maximum jerk, acceleration, and velocity. The pick and place motion (PPM) and resulting frame vibration are analyzed in frequency domain. Quantitative analysis shows that frame vibration can be reduced by altering those dynamic motion parameters. Because the analytic model is derived based on several simplifications, it cannot be directly applied. A surrogate model-based optimization method is proposed to solve the practical issues. By directly executing the PPM with different parameters and measuring the vibration, a model is derived using Gaussian Process Regression (GPR). In order to reduce the frame vibration without sacrificing robot efficiency, those two goals are fused together according to their priorities. Based on the surrogate model, a single objective optimization problem is formulated and solved by Genetic Algorithm (GA). Experimental results show effectiveness of the proposed method. Behavior of the optimal parameters also verifies the robot-frame vibration mechanism.