Dynamic establishment and maintenance of the human intestinal B cell population and repertoire following transplantation
Jianing Fu,
Thomas Hsiao,
Elizabeth Waffarn
et al.
Abstract:It is unknown how intestinal B cell populations and B cell receptor (BCR) repertoires are established and maintained over time in humans. Following intestinal transplantation (ITx), surveillance ileal mucosal biopsies provide a unique opportunity to map the dynamic establishment of gut lymphocyte populations. Using polychromatic flow cytometry that includes HLA allele group-specific mAbs distinguishing donor from recipient cells along with high throughput BCR sequencing, we tracked the establishment of recipie… Show more
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