Dynamic focus optical coherence tomography: feasibility for improved basal cell carcinoma investigation

Avanaki, Kamran; Aber, Ahmed; Hojjatoleslami, S. A.; Sira, Mano; Schofield, J. B.; Jones, C.A.; Podoleanu, Adrian Gh.

doi:10.1117/12.912081

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…We previously found three main features in the BCC OCT images: (1) lobular pattern of abnormal architecture, (2) dilated blood vessels, and (3) highly reflective margins. In addition to these [35][36][37][38] features, by using the DF-OCT, some new features associated with BCC were identified. These features are as follows: (a) irregular architecture of the skin layers (Fig.…”

Section: Resultsmentioning

confidence: 99%

Investigation of basal cell carcinoma using dynamic focus optical coherence tomography

et al. 2013

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Optical coherence tomography (OCT) is becoming a popular modality for skin tumor diagnosis and assessment of tumor size and margin status. We conducted a number of imaging experiments on periocular basal cell carcinoma (BCC) specimens using an OCT configuration. This configuration employs a dynamic focus (DF) procedure where the coherence gate moves synchronously with the peak of the confocal gate, which ensures better signal strength and preservation of transversal resolution from all depths. A DF-OCT configuration is used to illustrate morphological differences between the BCC and its surrounding healthy skin in OCT images. The OCT images are correlated with the corresponding histology images. To the best of our knowledge, this is the first paper to look at DF-OCT imaging in examining periocular BCC.

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Section: Resultsmentioning

confidence: 99%

Investigation of basal cell carcinoma using dynamic focus optical coherence tomography

et al. 2013

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“…Examples of OCT, RCT, and ultrasonography images of melanoma are shown in Figure 9 . It should be noted that many of these imaging modalities are in the investigational phase (see [ 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ]); i.e., they are not regularly used in clinical practice as of yet, but they could provide promising options in the future when they are better understood and accessible.…”

Section: Melanoma Biomarkersmentioning

confidence: 99%

Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities

Hessler

Jalilian

et al. 2020

IJMS

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Melanoma is the deadliest form of skin cancer and remains a diagnostic challenge in the dermatology clinic. Several non-invasive imaging techniques have been developed to identify melanoma. The signal source in each of these modalities is based on the alteration of physical characteristics of the tissue from healthy/benign to melanoma. However, as these characteristics are not always sufficiently specific, the current imaging techniques are not adequate for use in the clinical setting. A more robust way of melanoma diagnosis is to “stain” or selectively target the suspect tissue with a melanoma biomarker attached to a contrast enhancer of one imaging modality. Here, we categorize and review known melanoma diagnostic biomarkers with the goal of guiding skin imaging experts to design an appropriate diagnostic tool for differentiating between melanoma and benign lesions with a high specificity and sensitivity.

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“…Therefore to produce a solid phantom, the ratio of 3 0.5∶1 epoxy to hardener should always be used. The solidness of the phantom is important in several applications; for instance, with OCT setups with horizontal sample arms, a dough-like phantom cannot be used [26][27][28].…”

Section: Phantom Recipementioning

confidence: 99%

Two applications of solid phantoms in performance assessment of optical coherence tomography systems

et al. 2013

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Virtual tissues (phantoms) are widely used for performance evaluation of imaging systems. Specific design of the phantom is necessary for the correct assessment of a system's parameters. In an effort to reduce the amount of time and energy spent making application-oriented phantoms, we describe procedures to make epoxy-resin solid phantoms based on Mie scattering theory, with two different scatterers: polystyrene and gold microspheres. The phantoms are specifically designed to be used in two applications: (a) the gold microspheres solid phantoms are used to estimate the point-spread function (PSF) of an optical coherence tomography (OCT) system, and (b) the polystyrene solid phantom are used to evaluate the performance of an OCT-images optical properties extraction (OPE) algorithm. Phantoms with differing combination of materials have been tested to achieve the most suitable combination for producing an accurate PSF for application (a) and a valid evaluation/parameter optimization of the algorithm in application (b). An en face time-domain dynamic focus OCT is used for imaging.

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Dynamic focus optical coherence tomography: feasibility for improved basal cell carcinoma investigation

Cited by 5 publications

References 17 publications

Investigation of basal cell carcinoma using dynamic focus optical coherence tomography

Investigation of basal cell carcinoma using dynamic focus optical coherence tomography

Melanoma Biomarkers and Their Potential Application for In Vivo Diagnostic Imaging Modalities

Two applications of solid phantoms in performance assessment of optical coherence tomography systems

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