Dynamic formation of nanostructured particles from vesicles via invertase hydrolysis for on-demand delivery

Fong, Wye-Khay; Sánchez‐Ferrer, Antoni; Ortelli, Francesco; Sun, Wenjie; Boyd, Ben J.; Mezzenga, Raffaele

doi:10.1039/c6ra26688f

Cited by 13 publications

(10 citation statements)

References 68 publications

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“…The molecular compositions, determining the properties of the lipid and amphiphile mixtures (lipid molecular shape, chain length, chain saturation, asymmetry of the hydrophobic moieties, headgroup polarity and size), govern the interfacial curvature and the elastic properties of the obtained membrane assemblies. Intermediate phases of unusual topologies and/or hierarchical organizations have been observed in amphiphilic systems of multicomponent compositions [42][43][44]. For instance, "mesh" phases have been reported with ternary self-assembled systems consisting of a nonionic surfactant, oil, and water [44].…”

Section: Introductionmentioning

confidence: 99%

A vesicle-to-sponge transition via the proliferation of membrane-linking pores in ω-3 polyunsaturated fatty acid-containing lipid assemblies

Angelova

Angelov

Garamus

et al. 2019

Journal of Molecular Liquids

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 Mixed membrane assemblies of monoolein and a -3 polyunsaturated fatty acid characterized by non-trivial porous topologies  Amphiphilic composition-triggered transition from a vesicle to a sponge structure at room temperature  Small-angle X-ray scattering (SAXS) patterns detect the internal nanostructure transformation due to curvature changes  Cryo-TEM imaging reveals a sequence of intermediate states upon the vesicle-to-sponge nanoparticle transition

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Section: Introductionmentioning

confidence: 99%

A vesicle-to-sponge transition via the proliferation of membrane-linking pores in ω-3 polyunsaturated fatty acid-containing lipid assemblies

Angelova

Angelov

Garamus

et al. 2019

Journal of Molecular Liquids

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“…The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side effects of drugs by controlled releasing them at a specific site of action. Nanoparticle stimuli-responsive systems have been designed to make use of certain cues to trigger delivery of the payload after the materials are administered to the biological environment. − This can be achieved via the exposure of nanoparticles to intrinsic physiological stimuli present at the disease site, such as decreased pH at tumors, low pH in stomach, and enzymatic reactions, or extrinsic factors that are initiated by externally applied stimuli (e.g., light, temperature, and magnetic fields).…”

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confidence: 99%

“…123 Recently, Fong et al designed responsive cubosomes that react to the enzyme invertase (a sucrose hydrolysis enzyme) using sugar ester additives to functionalize a PT or monolinolein-based cubic matrix and showed triggered release of encapsulated model drug− fluorescein. 114 Fong et al have also performed a thorough review of responsive self-assembled nanostructured lipid systems. 124 All reported responsive LCNP systems possess potential for better spatial-, temporal-, and dosage-control of drugs.…”

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confidence: 99%

Non-Lamellar Lyotropic Liquid Crystalline Lipid Nanoparticles for the Next Generation of Nanomedicine

et al. 2019

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Nonlamellar lyotropic liquid crystalline (LLC) lipid nanomaterials have emerged as a promising class of advanced materials for the next generation of nanomedicine, comprising mainly of amphiphilic lipids and functional additives self-assembling into two- and three-dimensional, inverse hexagonal, and cubic nanostructures. In particular, the lyotropic liquid crystalline lipid nanoparticles (LCNPs) have received great interest as nanocarriers for a variety of hydrophobic and hydrophilic small molecule drugs, peptides, proteins, siRNAs, DNAs, and imaging agents. Within this space, there has been a tremendous amount of effort over the last two decades elucidating the self-assembly behavior and structure–function relationship of natural and synthetic lipid-based drug delivery vehicles in vitro, yet successful clinical translation remains sparse due to the lack of understanding of these materials in biological bodies. This review provides an overview of (1) the benefits and advantages of using LCNPs as drug delivery nanocarriers, (2) design principles for making LCNPs with desirable functionalities for drug delivery applications, (3) current understanding of the LLC material–biology interface illustrated by more than 50 in vivo, preclinical studies, and (4) current patenting and translation activities in a pharmaceutical context. Together with our perspectives and expert opinions, we anticipate that this review will guide future studies in developing LCNP-based drug delivery nanocarriers with the objective of translating them into a key player among nanoparticle platforms comprising the next generation of nanomedicine for disease therapy and diagnosis.

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“…Lipid-based cubosomes and hexosomes are a class of lipid nanoparticles containing the intriguing non-lamellar lyotropic liquid crystalline (LLC) mesophases, i.e., the inverse bicontinuous cubic (Q II ) phase and the inverse hexagonal (H II ) phase, respectively, which are formed by amphiphilic lipid self-assembly in aqueous conditions (Figure 1) [1][2][3][4][5][6]. Over the past three decades, the unique multidimensional and porous structural characteristics [7][8][9] of the non-lamellar LLC mesophases within cubosomes and hexosomes have driven a considerable amount of interest in a range of biomedical applications, including drug delivery [10][11][12][13][14][15][16][17] theranostic application [18] and imaging [19][20][21][22]. The Q II phase inside cubosomes can be described as a continuous, tortuous lipid bilayer draped over an infinite periodic minimal surface and composed of two interpenetrating water channels, possessing a large interfacial area [23].…”

Section: Introductionmentioning

confidence: 99%

Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles

et al. 2021

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Non-lamellar lyotropic liquid crystalline (LLC) lipid nanoparticles contain internal multidimensional nanostructures such as the inverse bicontinuous cubic and the inverse hexagonal mesophases, which can respond to external stimuli and have the potential of controlling drug release. To date, the internal LLC mesophase responsiveness of these lipid nanoparticles is largely achieved by adding ionizable small molecules to the parent lipid such as monoolein (MO), the mixture of which is then dispersed into nanoparticle suspensions by commercially available poly(ethylene oxide)–poly(propylene oxide) block copolymers. In this study, the Reversible Addition-Fragmentation chain Transfer (RAFT) technique was used to synthesize a series of novel amphiphilic block copolymers (ABCs) containing a hydrophilic poly(ethylene glycol) (PEG) block, a hydrophobic block and one or two responsive blocks, i.e., poly(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate) (PTBA) and/or poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). High throughput small angle X-ray scattering studies demonstrated that the synthesized ABCs could simultaneously stabilize a range of LLC MO nanoparticles (vesicles, cubosomes, hexosomes, inverse micelles) and provide internal particle nanostructure responsiveness to changes of hydrogen peroxide (H2O2) concentrations, pH and temperature. It was found that the novel functional ABCs can substitute for the commercial polymer stabilizer and the ionizable additive in the formation of next generation non-lamellar lipid nanoparticles. These novel formulations have the potential to control drug release in the tumor microenvironment with endogenous H2O2 and acidic pH conditions.

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Dynamic formation of nanostructured particles from vesicles via invertase hydrolysis for on-demand delivery

Abstract: Controlled hydrolysis via invertase action alters molecular shape and therefore lipid curvature, consequently triggering the release of encapsulated drug.

Cited by 13 publications

References 68 publications

A vesicle-to-sponge transition via the proliferation of membrane-linking pores in ω-3 polyunsaturated fatty acid-containing lipid assemblies

A vesicle-to-sponge transition via the proliferation of membrane-linking pores in ω-3 polyunsaturated fatty acid-containing lipid assemblies

Non-Lamellar Lyotropic Liquid Crystalline Lipid Nanoparticles for the Next Generation of Nanomedicine

Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles

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