Dynamic functional connectivity changes in the triple networks and its association with cognitive impairment in hemodialysis patients

Cao, Jianghui; Liu, Guangzhi; Li, Xuekun; Zheng, Yue; Ren, Jipeng; Zhu, Wei; Wu, Baolin

doi:10.1002/brb3.2314

Cited by 5 publications

(8 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MPFC is an important region of the default mode network (DMN), parietal lobe, and hippocampus 24 . The DMN participates in many cognitive processing functions, including memory, self‐awareness, and attention 25 . This indicates that some brain areas in the DMN are sensitive to changes in hemoglobin levels.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Intravoxel incoherent motion to assess brain microstructure and perfusion in patients with end‐stage renal disease

Shi

Jiang

Zheng

et al. 2022

Journal of Neuroimaging

View full text Add to dashboard Cite

Background and Purpose: This study aimed to investigate the clinical value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in evaluating the brain microstructure and perfusion changes in end-stage renal disease (ESRD) patients. Methods: The routine head MRI sequences and IVIM were performed on 40 ESRD patients and 30 healthy subjects. The IVIM was executed with 10 b-values varying from 0 to 1000 seconds/mm 2 . All subjects were evaluated on neuropsychological test. Laboratory tests were conducted for ESRD patients. Results: Compared with the control group, increased slow apparent diffusion coefficient values (ADC slow ) were found in the left frontal lobe, hippocampus, bilateral temporal lobe, and the right occipital lobe (p < .05), and increased fast ADC values (ADC fast ) were found in all regions of interest (all p < .001) in ESRD patients. In ESRD patients, ADC fast in right frontal lobe (p = .041) and insular lobe (p = .045) was negatively correlated with the Montreal Cognitive Assessment score (MoCA), and ADC fast in the right parietal lobe (p = .009) and hippocampus (p = .041) had positive correlation with hemoglobin levels. Using receiver operating characteristics (ROC) analysis, ADC fast in the right frontal lobe, insular lobe, hippocampus, and parietal lobe separately showed fair to good efficacy in differentiating ESRD patients from healthy subjects, with the area under the ROC ranging from .853 to .903. Conclusions: The microstructure and perfusion of the brain were impaired in ESRD patients. ADC fast of the right frontal lobe, insular lobe, hippocampus, and parietal lobe could be effective biomarker for evaluating cognitive impairment in ESRD patients. K E Y W O R D S cognitive impairment, end-stage renal disease, hemodialysis, intravoxel incoherent motion imaging Recently, with the development of MRI technology, favorable conditions have been created for exploring cognitive dysfunction 930

show abstract

Section: Discussionmentioning

confidence: 99%

“…24 The DMN participates in many cognitive processing functions, including memory, self-awareness, and attention. 25 This indicates that some brain areas in the DMN are sensitive to changes in hemoglobin levels.…”

Section: Differentiating Esrd Subjects With Cognitive Impairment From...mentioning

confidence: 99%

Intravoxel incoherent motion to assess brain microstructure and perfusion in patients with end‐stage renal disease

Shi

Jiang

Zheng

et al. 2022

Journal of Neuroimaging

View full text Add to dashboard Cite

show abstract

“…All patients with ESRD and HCs were righted-handed, and had normal sight to complete the neuropsychological tests. Some of the study samples were selected from our recently published papers, which mainly focused on investigating alterations in whole-brain functional network topologies ( Wu et al, 2020a ) and in dynamic FC properties within the triple networks ( Cao et al, 2021 ) in patients with ESRD.…”

Section: Methodsmentioning

confidence: 99%

“…Up to now, only one study has been conducted to analyze resting-state FC dynamics in patients with ESRD. Based on a triple-network model [involving the salience network (SN), DMN, and central executive network], our recent study found that the dynamic FC within the triple networks was altered in HD patients compared to healthy controls (HCs) ( Cao et al, 2021 ). Although this study demonstrated abnormal dynamic FC properties in HD patients, it only focused on the triple networks rather than the whole-brain networks, and the dynamic graph metrics which quantifiably describe the dynamic whole brain performance were not examined.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease

Yan

Zheng

et al. 2022

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Dynamic functional connectivity (FC) analysis can capture time-varying properties of connectivity; however, studies focusing on dynamic FC in patients with end-stage renal disease (ESRD) are very limited. This is the first study to explore the dynamic aspects of whole-brain FC and topological properties in ESRD patients. Resting-state functional magnetic resonance imaging data were acquired from 100 ESRD patients [50 hemodialysis (HD) patients and 50 non-dialysis patients] and 64 healthy controls (HCs). Independent component analysis, a sliding-window approach and graph-theory methods were used to study the dynamic FC properties. The intrinsic brain FC were clustered into four configuration states. Compared with HCs, both patient groups spent longer time in State 3, in which decreased FC between subnetworks of the default mode network (DMN) and between the dorsal DMN and language network was observed in these patients, and a further reduction in FC between the DMN subnetworks was found in HD patients compared to non-dialysis patients. The number of transitions and the variability of global and local efficiency progressively decreased from that in HCs to that of non-dialysis patients to that of HD patients. The completion time of Trail Making Test A and Trail Making Test B positively correlated with the mean dwell time of State 3 and negatively correlated with the number of transitions in ESRD patients. Our findings suggest impaired functional flexibility of network connections and state-specific FC disruptions in patients with ESRD, which may underlie their cognitive deficits. HD may have an adverse effect on time-varying FC.

show abstract

“…Brain imaging studies demonstrated that functional and structural brain abnormalities in ESRD patients have been detected in several brain regions, including the prefrontal lobe, inferior parietal lobe, cingulate gyrus, precuneus, temporal lobe, hippocampus/parahippocampal gyrus, and insula [ 5–9 ]. There were also abnormalities in the default mode network (DMN) [ 10–12 ], executive control network (ECN) [ 10 , 12 ], sensorimotor network (SMN) [ 12 , 13 ], salience network (SN) [ 10 , 14 ], and affective-limbic network (ALN) [ 15 , 16 ], which are composed of the brain regions mentioned above. The impairment of these brain regions or networks was related to abnormalities in overall cognitive function, working memory, visuospatial/executive function, attention, processing speed, sensorimotor, and emotional processing in ESRD patients.…”

Section: Introductionmentioning

confidence: 99%

Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease

Fang,

Miao,

Zou

et al. 2023

Renal Failure

View full text Add to dashboard Cite

Background End-stage renal disease (ESRD) patients have functional and structural brain abnormalities. The cerebellum also showed varying degrees of damage. However, no studies on cerebellar-cerebral functional connectivity (FC) have been conducted in ESRD patients. This study aimed to investigate the changes in cerebellar-cerebral FC in ESRD patients and its relationship with neuropsychological and clinical indexes. Methods Resting-state functional magnetic resonance imaging and neuropsychological assessment were performed on 37 ESRD patients and 35 control subjects. Seed-based FC analysis was performed to investigate inter-group differences in cerebellar-cerebral FC. In addition, the relations of altered FC with the neuropsychological function and clinical indicators were analyzed in ERSD patients. Results ESRD patients exhibited alterations in cerebellar-cerebral FC involving the executive control network, default mode network, and affective-limbic network compared to control subjects (False discovery rate-corrected, p < 0.05). The altered cerebellar-cerebral FC was associated with the Montreal Cognitive Assessment Scale score ( p < 0.05), and correlated with serum creatinine and uric acid levels within the ESRD group ( p < 0.05). Conclusions The study indicates that cerebellar-cerebral FC is involved in the neural substrates of cognitive impairment in ESRD patients. The findings may provide clinically relevant new neuroimaging biomarkers for the neuropathological mechanisms underlying cognitive impairment of ESRD.

show abstract

Dynamic functional connectivity changes in the triple networks and its association with cognitive impairment in hemodialysis patients

Cited by 5 publications

References 50 publications

Intravoxel incoherent motion to assess brain microstructure and perfusion in patients with end‐stage renal disease

Intravoxel incoherent motion to assess brain microstructure and perfusion in patients with end‐stage renal disease

Abnormal Dynamic Functional Connectivity in Patients With End-Stage Renal Disease

Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease

Contact Info

Product

Resources

About