Dynamic functional disturbances of brain network in seizure-related cognitive outcomes

Guo, Jing; Qian, Wei; Zhao, Changgeng; Xiao, Bo; Feng, Li

doi:10.1016/j.eplepsyres.2017.12.005

Cited by 5 publications

(6 citation statements)

References 120 publications

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“…This shows that using network oscillations to investigate cognitive impairment is a viable treatment strategy. Many studies are becoming more interested in the impact of network oscillations on cognitive impairment, focusing on specific frequencies and amplitudes of oscillation ( Wilke et al, 2011 ; Ibrahim et al, 2012 ; Guo et al, 2018 ). However, the mechanism through which oscillatory reorganization influences cognitive impairment remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…As a starting point, we investigated the findings of prior studies on the topic. Previous research has shown a causal relationship between the pathophysiological mechanisms that cause seizures and the biology of cognitive impairment, with oscillations acting as one of the essential links ( Jensen et al, 2007 ; Guo et al, 2018 ). Gamma oscillations are closely associated with sustained learning and memory functions, and oscillation abnormalities may result in cognitive deficits ( Ibrahim et al, 2012 ; Guo et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…Previous research has shown a causal relationship between the pathophysiological mechanisms that cause seizures and the biology of cognitive impairment, with oscillations acting as one of the essential links ( Jensen et al, 2007 ; Guo et al, 2018 ). Gamma oscillations are closely associated with sustained learning and memory functions, and oscillation abnormalities may result in cognitive deficits ( Ibrahim et al, 2012 ; Guo et al, 2018 ). Cognitive memory may be disrupted by seizures caused by intermittent oscillations ( Binnie and Marston, 1992 ; Holmes and Lenck-Santini, 2006 ; Lévesque et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, seizure cessation is characterized by somewhat uniform oscillatory suppression ( Truccolo et al, 2014 ). Intermittent epileptiform discharges have remote inhibitory effects on cognition ( Shamshiri et al, 2017 ; Ung et al, 2017 ; Guo et al, 2018 ; Watson, 2018 ). However, the mechanisms and pathophysiology that control particular functions have yet to be entirely understood.…”

Section: Introductionmentioning

confidence: 99%

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Putative cause of seizure-induced cognitive alterations: The oscillatory reconfiguration of seizure network

Fan

Qi²,

Yang³

et al. 2023

Front. Neurosci.

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IntroductionThe dynamic reconfiguration of network oscillations is connected with cognitive processes. Changes in how neural networks and signaling pathways work are crucial to how epilepsy and related conditions develop. Specifically, there is evidence that prolonged or recurrent seizures may induce or exacerbate cognitive impairment. However, it still needs to be determined how the seizure brain configures its functional structure to shape the battle of strong local oscillations vs. slow global oscillations in the network to impair cognitive function.MethodsIn this paper, we aim to deduce the network mechanisms underlying seizure-induced cognitive impairment by comparing the evolution of strong local oscillations with slow global oscillations and their link to the resting state of healthy controls. Here, we construct a dynamically efficient network of pathological seizures by calculating the synchrony and directionality of information flow between nine patients’ SEEG signals. Then, using a pattern-based method, we found hierarchical modules in the brain’s functional network and measured the functional balance between the network’s local strong and slow global oscillations.Results and discussionAccording to the findings, a tremendous rise in strong local oscillations during seizures and an increase in slow global oscillations after seizures corresponded to the initiation and recovery of cognitive impairment. Specifically, during the interictal period, local strong and slow global oscillations are in metastable balance, which is the same as a normal cognitive process and can be switched easily. During the pre-ictal period, the two show a bimodal pattern of separate peaks that cannot be easily switched, and some flexibility is lost. During the seizure period, a single-peak pattern with negative peaks is showcased, and the network eventually transitions to a very intense strong local oscillation state. These results shed light on the mechanism behind network oscillations in epilepsy-induced cognitive impairment. On the other hand, the differential (similarity) of oscillatory reorganization between the local (non) epileptogenic network and the global network may be an emergency protective mechanism of the brain, preventing the spread of pathological information flow to more healthy brain regions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Putative cause of seizure-induced cognitive alterations: The oscillatory reconfiguration of seizure network

Fan

Qi²,

Yang³

et al. 2023

Front. Neurosci.

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“…The dynamic functional alterations of the brain network, such as interictal epileptic discharges (IEDs) in the temporal lobe, might influence seizure-related memory impairment in TLE ( Halasz et al, 2019 ). IEDs are defined as spikes or spike-wave complexes that occur individually or continuously without evidence of seizures ( Guo et al, 2018 ). It is well known that the characteristics of IEDs, including the spike frequency ( Aldenkamp and Arends, 2004 ; Ebus et al, 2012 ), localization ( Wolff et al, 2005 ; Ebus et al, 2012 ; Glennon et al, 2016 ), appearance time ( Fonseca et al, 2007 ; Filippini et al, 2013 ), and duration of serial spike-wave complexes ( Aldenkamp et al, 2005 ), may have effects on cognition.…”

Section: Introductionmentioning

confidence: 99%

Memory Deficit in Patients With Temporal Lobe Epilepsy: Evidence From Eye Tracking Technology

et al. 2021

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Objective: To explore quantitative measurements of the visual attention and neuroelectrophysiological relevance of memory deficits in temporal lobe epilepsy (TLE) by eye tracking and electroencephalography (EEG).Methods: Thirty-four TLE patients and twenty-eight healthy controls were invited to complete neurobehavioral assessments, cognitive oculomotor tasks, and 24-h video EEG (VEEG) recordings using an automated computer-based memory assessment platform with an eye tracker. Visit counts, visit time, and time of first fixation on areas of interest (AOIs) were recorded and analyzed in combination with interictal epileptic discharge (IED) characteristics from the bilateral temporal lobes.Results: The TLE patients had significantly worse Wechsler Digit Span scores [F(1, 58) = 7.49, p = 0.008]. In the Short-Term Memory Game with eye tracking, TLE patients took a longer time to find the memorized items [F(1, 57) = 17.30, p < 0.001]. They had longer first fixation [F(1, 57) = 4.06, p = 0.049] and more visit counts [F(1, 57) = 7.58, p = 0.008] on the target during the recall. Furthermore, the performance of the patients in the Digit Span task was negatively correlated with the total number of IEDs [r(28) = −0.463, p = 0.013] and the number of spikes per sleep cycle [r(28) = −0.420, p = 0.026].Conclusion: Eye tracking appears to be a quantitative, objective measure of memory evaluation, demonstrating memory retrieval deficits but preserved visual attention in TLE patients. Nocturnal temporal lobe IEDs are closely associated with memory performance, which might be the electrophysiological mechanism for memory impairment in TLE.

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Targeting gap junction in epilepsy: Perspectives and challenges

Qin

Jia

et al. 2019

Biomedicine & Pharmacotherapy

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Dynamic functional disturbances of brain network in seizure-related cognitive outcomes

Cited by 5 publications

References 120 publications

Putative cause of seizure-induced cognitive alterations: The oscillatory reconfiguration of seizure network

Putative cause of seizure-induced cognitive alterations: The oscillatory reconfiguration of seizure network

Memory Deficit in Patients With Temporal Lobe Epilepsy: Evidence From Eye Tracking Technology

Targeting gap junction in epilepsy: Perspectives and challenges

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