Dynamic glucose enhanced MRI of the placenta in a mouse model of intrauterine inflammation

Wu, Dan; Xu, Jiadi; Lei, Jun; McLane, Michael; Zijl, Peter C. van; Burd, Irina

doi:10.1016/j.placenta.2018.07.012

Cited by 9 publications

(9 citation statements)

References 53 publications

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“…The conventional onVDMP sequence is composed of a train of binomial pulses followed by an image acquisition module, as shown in Figure 1(b). 18–20 As a previous VDMP study suggested, 21 the fast-exchanging signal component decays during the mixing time. Hence, the mixing time between binomial pulses was set to zero in this study of hydroxyl groups in D-glucose under physiological conditions and the offset of the binomial pulses was set to the water resonance.…”

Section: Methodsmentioning

confidence: 80%

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D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

Chen

Wei

Chan

et al. 2020

J Cereb Blood Flow Metab

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In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min−1) compared to their wild-type counterpart (0.56 ± 0.1 min−1, p < 0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.

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Section: Methodsmentioning

confidence: 80%

“…Among various glucoCEST methods, on-resonance variable delay multiple pulse (onVDMP) MRI is promising due to its excellent labeling efficiency and sensitivity. 18–20 In this study, we applied onVDMP MRI to detect cerebral D-glucose uptake and CSF clearance in AD mice and demonstrate its feasibility in discriminating AD from normal mice.…”

Section: Introductionmentioning

confidence: 99%

D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

Chen

Wei

Chan

et al. 2020

J Cereb Blood Flow Metab

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“…S1A. The basic composition of the saturation module is a train of high-power binomial pulses (bp) with zero-bp interval and zero water resonance offset (22,35,36). The pulse shape was two bp, and the number of pulse pairs was four.…”

Section: Mri Experimentsmentioning

confidence: 99%

Altered d -glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI

et al. 2020

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Altered cerebral glucose uptake is one of the hallmarks of Alzheimer’s disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.

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“…For example, studies have shown that, in the brain tumors, the increase of glucoCEST signal correlates well with the changes in cerebral blood volume, glucose transporter, and BBB integrity [ 70 , 110 , 111 ]. GlucoCEST contrast has been suggested as an imaging biomarker for tumor aggressiveness [ 61 ] and inflammatory responses in the kidney [ 112 ] and placenta [ 113 ].…”

Section: Nutrients and Supplements For Cest Mrimentioning

confidence: 99%

Repurposing Clinical Agents for Chemical Exchange Saturation Transfer Magnetic Resonance Imaging: Current Status and Future Perspectives

2020

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Molecular imaging is becoming an indispensable tool to pursue precision medicine. However, quickly translating newly developed magnetic resonance imaging (MRI) agents into clinical use remains a formidable challenge. Recently, Chemical Exchange Saturation Transfer (CEST) MRI is emerging as an attractive approach with the capability of directly using low concentration, exchangeable protons-containing agents for generating quantitative MRI contrast. The ability to utilize diamagnetic compounds has been extensively exploited to detect many clinical compounds, such as FDA approved drugs, X-ray/CT contrast agents, nutrients, supplements, and biopolymers. The ability to directly off-label use clinical compounds permits CEST MRI to be rapidly translated to clinical settings. In this review, the current status of CEST MRI based on clinically available compounds will be briefly introduced. The advancements and limitations of these studies are reviewed in the context of their pre-clinical or clinical applications. Finally, future directions will be briefly discussed.

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Dynamic glucose enhanced MRI of the placenta in a mouse model of intrauterine inflammation

Abstract: DGE-MRI is useful for evaluating placental functions related to glucose utilization. The technique uses a non-toxic biodegradable agent (d-glucose) and thus has a potential for rapid translation to human studies of placental disorders.

Cited by 9 publications

References 53 publications

D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

Altered d -glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI

Repurposing Clinical Agents for Chemical Exchange Saturation Transfer Magnetic Resonance Imaging: Current Status and Future Perspectives

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