Dynamic hydrogels produced via monoamine oxidase B-catalyzed deamination and aldimine crosslinking for 3D printing

Wei, Qingcong; Xu, Wei; Zhang, Qi; Zhang, Shuang; Cheng, Liming; Wang, Qigang

doi:10.1039/c7tb01108c

Cited by 25 publications

(32 citation statements)

References 34 publications

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“…When the dynamic covalent cross-linking density is high, the viscosity of the inkm ay be too high to extrude. Am odified dynamic covalent cross-linking method [97] was demonstrated by gradually introducing dialdehydec ross-linkers througha n enzyme-catalyzed reaction. In this ink, amino-polysaccharides, dibenzylamine-PEG, H 2 O 2 catalase, and the enzymem onoamine oxidase B( MAO B) are mixed together.I nt he presence of H 2 O 2 catalase, MAO Ba ctively converts the dibenzylamine-PEG to dialdehyde-PEG, the latter subsequently cross-linking the polysaccharides.…”

Section: Dynamic Covalent Chemistrymentioning

confidence: 99%

“…When the dynamic covalent cross‐linking density is high, the viscosity of the ink may be too high to extrude. A modified dynamic covalent cross‐linking method was demonstrated by gradually introducing dialdehyde cross‐linkers through an enzyme‐catalyzed reaction. In this ink, amino‐polysaccharides, dibenzylamine‐PEG, H 2 O 2 catalase, and the enzyme monoamine oxidase B (MAO B) are mixed together.…”

Section: Facilitating 3d Printability To Polymersmentioning

confidence: 99%

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Advanced Polymer Designs for Direct‐Ink‐Write 3D Printing

Lin

Tang

et al. 2019

Chemistry A European J

194

161

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The rapid development of additive manufacturing techniques, also known as three‐dimensional (3D) printing, is driving innovations in polymer chemistry, materials science, and engineering. Among current 3D printing techniques, direct ink writing (DIW) employs viscoelastic materials as inks, which are capable of constructing sophisticated 3D architectures at ambient conditions. In this perspective, polymer designs that meet the rheological requirements for direct ink writing are outlined and successful examples are summarized, which include the development of polymer micelles, co‐assembled hydrogels, supramolecularly cross‐linked systems, polymer liquids with microcrystalline domains, and hydrogels with dynamic covalent cross‐links. Furthermore, advanced polymer designs that reinforce the mechanical properties of these 3D printing materials, as well as the integration of functional moieties to these materials are discussed to inspire new polymer designs for direct ink writing and broadly 3D printing.

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Section: Dynamic Covalent Chemistrymentioning

confidence: 99%

Section: Facilitating 3d Printability To Polymersmentioning

confidence: 99%

Advanced Polymer Designs for Direct‐Ink‐Write 3D Printing

Lin

Tang

et al. 2019

Chemistry A European J

194

161

View full text Add to dashboard Cite

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“…Monoamine oxidase B (MOA-B) specifically transforms benzylamine into benzaldehyde through a benziminium intermediate. Consequently, Wei et al 182 have used MOA-B to turn bifunctional PEG terminated by 4-aminomethyl benzoic acid into its dibenzaldehyde counterpart, which reacted as a bifunctional cross-linker with primary amines of glycol chitosan or gelatin yielding Schiff base linkages (Fig. 30).…”

Section: Enzymatic Activation Of Gelationmentioning

confidence: 99%

Chemical insights into bioinks for 3D printing

et al. 2019

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“…Enzyme monoamine oxidase B (MAO B) was used by Wei et al in 2017 to deaminate the benzylamine-difunctionalized poly(ethylene glycol) (PEG-BA) to produce the corresponding aldehyde product (PEG-AL), which became useful for cross-linking the amine-containing macromolecules such as glycol chitosan or gelatin to form dynamic hydrogels. 68 Another enzyme catalase (CAT) was also employed to decompose the byproduct H 2 O 2 from the previous MAO B-catalyzed reaction. The reversible imide bonds produced by enzymatic reactions endowed the hydrogels with an excellent healing ability and multiresponsibility.…”

Section: Enzymatic Fabrication Of Healable Polymeric Hydrogelsmentioning

confidence: 99%

Enzyme-Regulated Healable Polymeric Hydrogels

Zhong

et al. 2020

ACS Cent. Sci.

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The enzyme-regulated healable polymeric hydrogels are a kind of emerging soft material capable of repairing the structural defects and recovering the hydrogel properties, wherein their fabrication, self-healing, or degradation is mediated by enzymatic reactions. Despite achievements that have been made in controllable cross-linking and de-cross-linking of hydrogels by utilizing enzyme-catalyzed reactions in the past few years, this substrate-specific strategy for regulating healable polymeric hydrogels remains in its infancy, because both the intelligence and practicality of current man-made enzyme-regulated healable materials are far below the levels of living organisms. A systematic summary of current achievements and a reasonable prospect at this point can play positive roles for the future development in this field. This Outlook focuses on the emerging and rapidly developing research area of bioinspired enzyme-regulated self-healing polymeric hydrogel systems. The enzymatic fabrication and degradation of healable polymeric hydrogels, as well as the enzymatically regulated self-healing of polymeric hydrogels, are reviewed. The functions and applications of the enzyme-regulated healable polymeric hydrogels are discussed.

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Dynamic hydrogels produced via monoamine oxidase B-catalyzed deamination and aldimine crosslinking for 3D printing

Abstract: Dynamic hydrogels of amino-containing polysaccharides (or proteins) and benzylamine-difunctionalized PEG were prepared via an oxidative deamination reaction catalyzed by MAO B.

Cited by 25 publications

References 34 publications

Advanced Polymer Designs for Direct‐Ink‐Write 3D Printing

Advanced Polymer Designs for Direct‐Ink‐Write 3D Printing

Chemical insights into bioinks for 3D printing

Enzyme-Regulated Healable Polymeric Hydrogels

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