2024
DOI: 10.3389/fimmu.2024.1380211
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Dynamic immune status analysis of peripheral blood mononuclear cells in patients with Klebsiella pneumoniae bloodstream infection sepsis using single-cell RNA sequencing

Shengwei Zhang,
Nan Zhang,
Jing Han
et al.

Abstract: BackgroundKlebsiella pneumoniae is a common Gram-negative bacterium. Blood infection caused by K. pneumoniae is one of the most common causes of human sepsis, which seriously threatens the life of patients. The immune status of peripheral blood mononuclear cells (PBMCs) based on single-cell RNA sequencing (scRNA-seq) in acute stage and recovery stage of sepsis caused by K. pneumoniae bloodstream infection has not been studied.MethodsA total of 13 subjects were included in this study, 3 healthy controls, 7 pati… Show more

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