1998
DOI: 10.1083/jcb.141.1.287
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Dynamic Interaction of PTPμ with Multiple Cadherins In Vivo

Abstract: There is a growing body of evidence to implicate reversible tyrosine phosphorylation as an important mechanism in the control of the adhesive function of cadherins. We previously demonstrated that the receptor protein tyrosine phosphatase PTPμ associates with the cadherin–catenin complex in various tissues and cells and, therefore, may be a component of such a regulatory mechanism (Brady-Kalnay, S.M., D.L. Rimm, and N.K. Tonks. 1995. J. Cell Biol. 130:977– 986). In this study, we present further characterizati… Show more

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Cited by 173 publications
(193 citation statements)
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“…Shc is known to interact physically with PP2A (Ugi et al 2002) and cadherin (Xu et al 1997). Cadherins can also interact with a receptor-type protein tyrosine phosphatase (Brady-Kalnay et al 1998), in agreement with the presence of both cadherin and receptor-type protein tyrosine phosphatase in the IGF-2 group (Fig. 4).…”
Section: Genome Research 2711supporting
confidence: 71%
“…Shc is known to interact physically with PP2A (Ugi et al 2002) and cadherin (Xu et al 1997). Cadherins can also interact with a receptor-type protein tyrosine phosphatase (Brady-Kalnay et al 1998), in agreement with the presence of both cadherin and receptor-type protein tyrosine phosphatase in the IGF-2 group (Fig. 4).…”
Section: Genome Research 2711supporting
confidence: 71%
“…The present results suggest that gap junctions in non-transformed cells might be targets for tyrosine kinases along with other types of cellular junctions and adhesion molecules [44][45][46][47]. The normal content of phosphotyrosine in Cx43 is clearly below the limit of detection.…”
Section: Discussionmentioning
confidence: 63%
“…This is even more intriguing since a molecular cross-talk between Wnt and EGF signalling is well known (Dierick and Bejsovec, 1999). Besides the kinases, several protein tyrosine phosphatases have been linked to b-catenin function (Hoschuetzky et al, 1994;Brady-Kalnay et al, 1995;Kypta et al, 1996). Future work will reveal which of the kinases or phosphatases is crucial for maintaining b-catenin in a dephosphorylated state in the case of sFRP-mediated signaling.…”
Section: Discussionmentioning
confidence: 99%