Dynamic Interfacial Adhesion through Cucurbit[n]uril Molecular Recognition

Abstract

Supramolecular building blocks,s uch as cucurbit-[n]uril (CB[n])-based host-guest complexes,have been extensively studied at the nano-and microscale as adhesion promoters.H erein, we exploit an ew class of CB[n]-threaded highly branched polyrotaxanes (HBP-CB[n]) as aqueous adhesives to macroscopically bond two wet surfaces,including biological tissue,through the formation of CB[8] heteroternary complexes.The dynamic nature of these complexes gives rise to adhesion with remarkable toughness,d isplaying recovery and reversible adhesion upon mechanical failure at the interface. Incorporation of functional guests,s uch as azobenzene moieties,a llows for stimuli-activated on-demand adhesion/ de-adhesion. Macroscopic interfacial adhesion through dynamic host-guest molecular recognition represents an innovative strategy for designing the next generation of functional interfaces,b iomedical devices,t issue adhesives,a nd wound dressings.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

“…2c, d, e and Supplementary Fig. 11) 45,46 . The NPA 2 coacervate-bonded porcine skin joints can withstand an applied force five times greater than that of the homolog control groups (NPA 1 nanoparticle solution and NPA 3 coacervate).…”

Supramolecular adhesive materials from small‐molecule self‐assembly

“…35 CDs are known for exhibiting weak bonding in water (association constant, K a ≈ 10 6 ), whereas the other class of hosts with better performance, CBs have been extensively studied in recent years. 75,76 Liu and coworkers 77,78 introduced CB [8] into the polyacrylic networks to form tough and healable hydrogel adhesives, and azobenzene (AZO) was also combined for dynamic interfacial adhesion. But the substrate-binding was dependent on physical adsorption of polymer chains through van der Waals interactions.…”

Tough Hydrogel Bioadhesives for Sutureless Wound Sealing, Hemostasis and Biointerfaces

“…The tough and instant interfacial adhesion arose from the synergetic contribution from both noncovalent interactions (i.e., hydrogen bonding and electrostatic interactions) and covalent bonds between the NHS (adhesive side) and amine groups (tissue side) (Figure 1c). [22,23] Previously, a wide variety of hydrogel bioadhesives have been reported either from monomer precursors, [22,24,25] in situ gelation of functional polymer solution, [12,[26][27][28] biopolymer solutions (i.e., silk), [29][30][31] or DOPAinspired adhesives [31,32] (Table S1, Supporting Information). These systems represent strategies to construct hydrogel networks as bioadhesives, however, might be challenged by the residues of monomers or other small-molecule residues, which could induce undesirable immunological side-effects during the in vivo applications.…”