Dynamic intra‐epidermal bodies (<scp>IEB</scp>s) in koi epidermis

DePasquale, Joseph A.

doi:10.1111/azo.12226

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Changes in ion composition of the extracellular milieu (Daborn et al, ) or exposure to metals such as copper (Mela et al, ) also have an impact on microridge patterns. Large‐scale intra‐epidermal events (DePasquale, ) result in transient distortions in the arrangement of microridges. Hormones and changes in salinity can affect microridge patterns, such as observed in adult guppies after prolactin treatment (Schwerdtfeger, ) or in catfish ( Pimelodus maculatus ) exposed to increased sodium chloride levels (Ferri, ).…”

Section: Patternsmentioning

confidence: 99%

Actin Microridges

DePasquale

2018

The Anatomical Record

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Microridges are highly distinctive “fingerprint”‐patterned structures situated on the outer surface of superficial layer cells of the epithelium. An F‐actin‐based cytoskeleton is the underlying core structural component of microridges. The basis for much of what is known about microridges has been provided by in vivo and in vitro fish epithelial systems. Nonetheless the microridge literature is quite small, especially when compared with other actin‐based cellular structures such as those involved in cell motility. A PubMed search of the terms “Microridges” yields 261 citations from the mid‐1970s to the writing of this review. “Microplicae,” an alternative name for microridges, and “Actin Microridges” search terms give 204 and 8 references, respectively, in the same time period. By comparison a search of “Lamellipodia” over the same time period yields over 6,400 citations for this important motility structure while a search of the associated “filopodia” results in close to 7,300 articles. Despite the near‐ubiquity of microridges in epithelia across species the study of these structures has clearly been neglected. In‐depth analysis of microridge molecular composition is very limited while their function remains unclear. This review draws upon information derived from studies of fish as well as mammalian species to provide a more comprehensive view of these structures. The wide‐spread distribution of these structures between species and various tissues indicate the microridges have important and common functions in healthy organisms. Conversely, disease conditions may show alterations in microridge structure and function and thus warrant further investigation. Anat Rec, 301:2037–2050, 2018. © 2018 Wiley Periodicals, Inc.

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Section: Patternsmentioning

confidence: 99%

Actin Microridges

DePasquale

2018

The Anatomical Record

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Formation of Intra‐Epidermal bodies (IEBs) is associated with giant macrophage‐like cells that patrol fish epidermis

DePasquale

2023

Acta Zoologica

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Intra‐epidermal bodies (IEBs) are large dynamic circular structures that form within fish scale epidermis. IEBs are believed to reflect the sequestering of intra‐epidermal debris, such as damaged or dead cells, within the epidermis. The present report describes an association between a giant cell that patrols the epidermis and the formation of IEBs. The giant cell, likely macrophage‐related, is a broadly spread cell with lengths up to ~90 μm and average spread areas >600 μm2. Time‐lapse video microscopy was used to monitor formation of IEBs and determine any association between the IEB and the giant cells. Giant cells were observed to form IEBs, and as an IEB dissipated a giant cell was observed to exit the area previously occupied by the IEB. These observations suggest the IEB is a transitional form of the giant cell, serving as a temporary compartment to isolate and initiate breakdown of the debris scavenged by the giant cell.

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Dynamic intra‐epidermal bodies (IEBs) in koi epidermis

Cited by 2 publications

References 18 publications

Actin Microridges

Actin Microridges

Formation of Intra‐Epidermal bodies (IEBs) is associated with giant macrophage‐like cells that patrol fish epidermis

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